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Laurdan

Name: Laurdan
Brand: TargetMol
SKU: T20642
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T20642Cas No. 74515-25-6

Alias 6-Dodecanoyl-2-dimethylaminonaphthalene

Laurdan (6-Dodecanoyl-2-dimethylaminonaphthalene) is a fluorescent membrane probe that is spectrally sensitive to the phospholipid phase of the cell membrane to which it binds.

Laurdan

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Purity: 99.02%

Catalog No. T20642Alias 6-Dodecanoyl-2-dimethylaminonaphthaleneCas No. 74515-25-6

Laurdan (6-Dodecanoyl-2-dimethylaminonaphthalene) is a fluorescent membrane probe that is spectrally sensitive to the phospholipid phase of the cell membrane to which it binds.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
5 mg	$29	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$30	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.02%

Appearance:Solid

Color:Yellow

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	Laurdan (6-Dodecanoyl-2-dimethylaminonaphthalene) is a fluorescent membrane probe that is spectrally sensitive to the phospholipid phase of the cell membrane to which it binds.
Cell Research	Laurdan as a biosensor to monitor changes in membrane water content during NIH3T3 cell migration I. Solution preparation 1. Preparation of storage solution: Dissolve Laurdan in dimethyl sulfoxide (DMSO) to prepare a 1.8 mM stock solution. 2. Preparation of working solution: Dilute the Laurdan stock solution at a dilution of 1:1000. II. Operation steps 1. Culture NIH3T3 cells in Dulbecco's modified Eagle medium supplemented with 10% fetal bovine serum, 5 mL Pen-Strep, and 2.5 mL 1 M HEPES. 2. Seed freshly isolated NIH3T3 cells into 35 mm Mattek glass-bottom culture dishes coated with fibronectin. 3. Incubate the cells with Laurdan at 37°C for 40 min. 4. Observe using an LSM710 META laser scanning microscope. 5. Calibration of the system and phasor plot of FLIM data by measuring fluorescein (pH 11). The above information is based on published literature. Experimental procedures should be appropriately modified to meet specific research demands.
Synonyms	6-Dodecanoyl-2-dimethylaminonaphthalene

Chemical Properties

Molecular Weight	353.54
Formula	C₂₄H₃₅NO
Cas No.	74515-25-6
Smiles	CCCCCCCCCCCC(=O)c1ccc2cc(ccc2c1)N(C)C
Relative Density.	0.987g/cm3

Storage & Solubility Information

Storage

keep away from direct sunlight,store at low temperature | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 10 mg/mL (28.29 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 1 mg/mL (2.83 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8285 mL	14.1427 mL	28.2853 mL	141.4267 mL
5 mM	0.5657 mL	2.8285 mL	5.6571 mL	28.2853 mL
10 mM	0.2829 mL	1.4143 mL	2.8285 mL	14.1427 mL
20 mM	0.1414 mL	0.7071 mL	1.4143 mL	7.0713 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc