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Lynestrenol

Name: Lynestrenol
Brand: TargetMol
SKU: T7974
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T7974Cas No. 52-76-6

Lynestrenol is a synthetic progestational hormone, is the progesterone receptor agonist

Lynestrenol

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Purity: 99.94%

Catalog No. T7974Cas No. 52-76-6

Lynestrenol is a synthetic progestational hormone, is the progesterone receptor agonist

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$30	In Stock	In Stock
25 mg	$48	In Stock	In Stock
50 mg	$78	In Stock	In Stock
100 mg	$127	In Stock	In Stock
500 mg	$315	-	In Stock
1 mL x 10 mM (in DMSO)	$42	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.94%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Lynestrenol AI Summary

Lynestrenol exhibits moderate acute and cholestatic liver toxicity but does not show severe liver-related bioactivities such as hepatitis, chronic liver disease, cirrhosis, or liver tumors. It binds differentially to progesterone receptors in various species, with moderate affinity in humans and sheep, higher affinity in rabbits, and lower affinity in guinea pigs. In antiviral studies, it shows limited efficacy against SARS-CoV-2, with an inhibition index of -0.1212 in Vero E6 cells and modest inhibition percentages in other assays. It also shows inhibition of human HDAC6 enzyme activity at low percentages. Lynestrenol interacts with multiple receptors and proteins, displaying varied bioactivities, including antagonist and agonist effects on receptors such as HRH2, ADRA1A, and CNR1. Additionally, it has been evaluated for enzyme inhibition, showing low activity against enzymes like PTGS2 and PDE4D..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

Lynestrenol is a synthetic progestational hormone, is the progesterone receptor agonist

Chemical Properties

Molecular Weight	284.44
Formula	C₂₀H₂₈O
Cas No.	52-76-6
Smiles	[H][C@]12CC[C@](O)(C#C)[C@]1(C)CC[C@@]1([H])[C@]3([H])CCCC=C3CC[C@]21[H]
Relative Density.	1.0083 g/cm3 (Estimated)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 56 mg/mL (196.88 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (7.03 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.5157 mL	17.5784 mL	35.1568 mL	175.7840 mL
5 mM	0.7031 mL	3.5157 mL	7.0314 mL	35.1568 mL
10 mM	0.3516 mL	1.7578 mL	3.5157 mL	17.5784 mL
20 mM	0.1758 mL	0.8789 mL	1.7578 mL	8.7892 mL
50 mM	0.0703 mL	0.3516 mL	0.7031 mL	3.5157 mL
100 mM	0.0352 mL	0.1758 mL	0.3516 mL	1.7578 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc