Anti-CDK4 Antibody (6D570)

Name: Anti-CDK4 Antibody (6D570)
Brand: TargetMol
SKU: TMAB-00406
Rating: 4.5 (1 reviews)

(Synonyms: PSK-J3, cyclin-dependent kinase 4, CMM3) Copy Product Info

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Synonyms: PSK-J3, cyclin-dependent kinase 4, CMM3

Catalog No. TMAB-00406 Copy Product Info

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Anti-CDK4 Antibody (6D570) is a Mouse antibody targeting CDK4. Anti-CDK4 Antibody (6D570) can be used in ICC/IF, IF, IHC-Fr, IHC-P, WB.

Anti-CDK4 Antibody
(6D570)

Pack Size	Price	USA Stock	Global Stock	Quantity
50 μL	$296	7-10 days	7-10 days
100 μL	$489	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Instruction Manual of Detection Antibody

Product Introduction

Bioactivity

Description	Anti-CDK4 Antibody (6D570) is a Mouse antibody targeting CDK4. Anti-CDK4 Antibody (6D570) can be used in ICC/IF, IF, IHC-Fr, IHC-P, WB.
Synonyms	PSK-J3, cyclin-dependent kinase 4, CMM3
Ig Type	IgG
Clone	6D570
Reactivity	Human,Mouse,Rat

Application	ICC/IF IF IHC-Fr IHC-P WB
Recommended Dose	ICC/IF=1:50-200; IF=1:200-1000; IHC-Fr=1:200-1000; IHC-P=1:200-1000; WB=1:500-2000
Antibody Type	Monoclonal
Host Species	Mouse
Subcellular Localization	Cytoplasm. Nucleus. Membrane. Cytoplasmic when non-complexed. Forms a cyclin D-CDK4 complex in the cytoplasm as cells progress through G(1) phase. The complex accumulates on the nuclear membrane and enters the nucleus on transition from G(1) to S phase. Also present in nucleoli and heterochromatin lumps. Colocalizes with RB1 after release into the nucleus.
Construction	Hybridoma Monoclonal Antibody
Purification	Protein A purified
Appearance	Liquid
Formulation	0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Concentration	1 mg/mL
Research Background	The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported. [provided by RefSeq, Jul 2008]

Antigen Details

Immunogen	KLH conjugated synthetic peptide: human Cdk4
Antigen Species	Human
Gene Name	CDK4
Gene ID	1019
Protein Name	Cyclin-dependent kinase 4 Cyclin-dependent kinase 4
Uniprot ID	P11802
Biology Area	Cdk4,Cdks,Cdks,Cdks
Function	Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also phosphorylates SMAD3 in a cell-cycle-dependent manner and represses its transcriptional activity. Component of the ternary complex, cyclin D/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.