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MF-094

Name: MF-094
Brand: TargetMol
SKU: T12024
Price: 36 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T12024Cas No. 2241025-68-1

MF-094 is a selective USP30 inhibitor with IC50 of 0.12 μM. MF-094 can increase protein ubiquitination and accelerate mitophagy.

MF-094

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Purity: 99.93%

Catalog No. T12024Cas No. 2241025-68-1

MF-094 is a selective USP30 inhibitor with IC50 of 0.12 μM. MF-094 can increase protein ubiquitination and accelerate mitophagy.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$36	In Stock	In Stock
5 mg	$89	In Stock	In Stock
10 mg	$147	In Stock	In Stock
25 mg	$297	In Stock	In Stock
50 mg	$478	In Stock	In Stock
100 mg	$689	In Stock	In Stock
200 mg	$983	-	In Stock
1 mL x 10 mM (in DMSO)	$106	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.93%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	MF-094 is a selective USP30 inhibitor with IC50 of 0.12 μM. MF-094 can increase protein ubiquitination and accelerate mitophagy.
Targets&IC50	USP30:120 nM
In vitro	In hypoxic trophoblast cells supplemented with MF-094, GSH and SOD levels increased, while MDA levels decreased. [2]
In vivo	Subcutaneous injection of MF-094 can promote the ubiquitination level of FUNDC1. MF-094 can significantly reduce the increase in systolic blood pressure and urine protein in PE mice. [2]

Chemical Properties

Molecular Weight	535.7
Formula	C₃₀H₃₇N₃O₄S
Cas No.	2241025-68-1
Smiles	CC(C)(C)NS(=O)(=O)c1cccc2c(NC(=O)[C@H](Cc3ccccc3)NC(=O)C3CCCCC3)cccc12
Relative Density.	1.229 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 150 mg/mL (280.01 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8667 mL	9.3336 mL	18.6672 mL	93.3358 mL
5 mM	0.3733 mL	1.8667 mL	3.7334 mL	18.6672 mL
10 mM	0.1867 mL	0.9334 mL	1.8667 mL	9.3336 mL
20 mM	0.0933 mL	0.4667 mL	0.9334 mL	4.6668 mL
50 mM	0.0373 mL	0.1867 mL	0.3733 mL	1.8667 mL
100 mM	0.0187 mL	0.0933 mL	0.1867 mL	0.9334 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc