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MAP4K4-IN-3
🥰Excellent
Catalog No. T11942Cas No. 1811510-58-3
Alias Compound 17
MAP4K4-IN-3 (Compound 17), a serine/threonine protein kinase, may be a viable target for antidiabetic agents.
MAP4K4-IN-3
🥰Excellent
Purity: 98.07%
Catalog No. T11942Alias Compound 17Cas No. 1811510-58-3
MAP4K4-IN-3 (Compound 17), a serine/threonine protein kinase, may be a viable target for antidiabetic agents.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $39 | In Stock | |
| 10 mg | $72 | In Stock | |
| 25 mg | $155 | In Stock | |
| 50 mg | $247 | In Stock | |
| 100 mg | $393 | In Stock | |
| 200 mg | $582 | In Stock | |
| 500 mg | $885 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $43 | In Stock |
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Purity:98.07%
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Product Introduction
Bioactivity
Chemical Properties
| Description | MAP4K4-IN-3 (Compound 17), a serine/threonine protein kinase, may be a viable target for antidiabetic agents. |
| Targets&IC50 | MAP4K4:14.9 nM |
| In vitro | MAP4K4-IN-3, Antidiabetic agent.MAP4K4-IN-3 is a potent and selective MAP4K4 inhibitor with an IC50 of 14.9 nM in kinase assay, an IC50 of 470 nM in cell assay. |
| In vivo | Administering MAP4K4-IN-3 (Compound 2; 25 mg/kg, b.i.d.) orally to telemetered rats over a period of five days induces several adverse reactions. Cardiovascular measurements reveal a significant increase in maximal heart rate by 25 beats per minute (bpm) compared to control groups upon treatment with MAP4K4-IN-3[2]. Additionally, there are noticeable declines in body weight (7%) and an increase in body temperature (0.4°C) against control values throughout the study. |
| Synonyms | Compound 17 |
| Molecular Weight | 297.74 |
| Formula | C15H12ClN5 |
| Cas No. | 1811510-58-3 |
| Smiles | Nc1ncc(cn1)-c1cnc(N)c(c1)-c1ccc(Cl)cc1 |
| Relative Density. | 1.377 g/cm3 (Predicted) |
| Color | White |
| Appearance | Solid |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 8 mg/mL (26.87 mM), Sonication is recommended. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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