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Anti-TLR9 Polyclonal Antibody
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Catalog No. TMAB-01861
Alias Toll-like receptor 9, Toll like receptor 9 isoform B, Toll like receptor 9 isoform A precursor, Toll like receptor 9, TLR 9, CD289, CD 289
Anti-TLR9 Polyclonal Antibody is a Rabbit antibody targeting TLR9. Anti-TLR9 Polyclonal Antibody can be used in WB.
Anti-TLR9 Polyclonal Antibody
Anti-TLR9 Polyclonal Antibody
😃Good
Catalog No. TMAB-01861Alias Toll-like receptor 9, Toll like receptor 9 isoform B, Toll like receptor 9 isoform A precursor, Toll like receptor 9, TLR 9, CD289, CD 289
Anti-TLR9 Polyclonal Antibody is a Rabbit antibody targeting TLR9. Anti-TLR9 Polyclonal Antibody can be used in WB.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μL | $220 | 7-10 days | |
| 100 μL | $373 | 7-10 days | |
| 200 μL | $529 | 7-10 days |
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-TLR9 Polyclonal Antibody is a Rabbit antibody targeting TLR9. Anti-TLR9 Polyclonal Antibody can be used in WB. |
| Synonyms | Toll-like receptor 9, Toll like receptor 9 isoform B, Toll like receptor 9 isoform A precursor, Toll like receptor 9, TLR 9, CD289, CD 289 |
| Ig Type | IgG |
| Reactivity | Human,Mouse |
| Verified Activity | 1. Sample: Testis (Mouse) Lysate at 40 μg Primary: Anti-TLR9 (TMAB-01861) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 113 kDa Observed band size: 120 kDa 2. Sample: Lane 1: Human SH-SY5Y cell lysates Lane 2: Human HeLa cell lysates Primary: Anti-TLR9 (TMAB-01861) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 113 kDa Observed band size: 120 kDa   |
| Application | |
| Recommended Dose | WB: 1:500-2000 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Endoplasmic reticulum membrane; Single-pass type I membrane protein. Endosome. Lysosome. Cytoplasmic vesicle, phagosome. Note=Relocalizes from endoplasmic reticulum to endosome and lysosome upon stimulation with agonist. |
| Tissue Specificity | Highly expressed in spleen, lymph node, tonsil and peripheral blood leukocytes, especially in plasmacytoid pre-dendritic cells. Levels are much lower in monocytes and CD11c+ immature dendritic cells. Also detected in lung and liver. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1 mg/mL |
| Research Background | The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is preferentially expressed in immune cell rich tissues, such as spleen, lymph node, bone marrow and peripheral blood leukocytes. Studies in mice and human indicate that this receptor mediates cellular response to unmethylated CpG dinucleotides in bacterial DNA to mount an innate immune response. [provided by RefSeq, Jul 2008] |
| Immunogen | KLH conjugated synthetic peptide: human TLR9 |
| Antigen Species | Human |
| Gene Name | TLR9 |
| Gene ID | |
| Protein Name | Toll-like receptor 9 |
| Uniprot ID | |
| Biology Area | Receptors,Macrophage / Inflamm.,TLR Signaling,Transmembrane |
| Function | Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Controls lymphocyte response to Helicobacter infection. |
| Molecular Weight | Theoretical: 113 kDa. |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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