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Serpin A5 Protein, Human, Recombinant (His)
(Synonyms: SERPINA5, Serpin A5, Protein C Inhibitor, PROCI, Plasminogen Activator Inhibitor 3, Plasma Serine Protease Inhibitor, PLANH3, PCI, PAI-3, PAI3, Acrosomal Serine Protease Inhibitor) Copy Product InfoSynonyms: SERPINA5, Serpin A5, Protein C Inhibitor, PROCI, Plasminogen Activator Inhibitor 3, Plasma Serine Protease Inhibitor, PLANH3, PCI, PAI-3, PAI3, Acrosomal Serine Protease Inhibitor
Catalog No. TMPJ-00490 Copy Product Info
Serpin A5 is a member of the human Serpin superfamily consists of at least 35 members. It is synthesized in the liver and has been detected in saliva, cerebral spinal fluid, amniotic fluid, tears and semen. As a potent inhibitor of the protein C anticoagulant pathway at the levels of both zymogen activation and enzyme inhibition, Serpin A5 additionally inhibits a variety of serine protease including thrombin, factor Xa, several kallekreins and acrosin. It plays a critical role in the processes of blood of blood coagulation and fertilization. Serpin A5 also inhibits urinary plasminogen activator (uPA), a mediator of tumor cell invasion, and regulates tumor growth and metastasis by inhibiting angiogenesis. Furthermore, recent studies have identified PCI as a potent and direct inhibitor of activated HGFA (hepatocyte growth factor activator), suggesting a novel function in the regulation of tissue repair and regeneration. Similar to Serpins C1 and D1, the thrombin inhibitory activity of serpinA5 is enhanced by heparin.
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 5 μg | $112 | 35 days | 35 days | |
| 10 μg | $183 | 35 days | 35 days | |
| 20 μg | $292 | 35 days | 35 days | |
| 50 μg | $545 | 35 days | 35 days | |
| 100 μg | $792 | 35 days | 35 days | |
| 200 μg | $1,150 | 35 days | 35 days | |
| 500 μg | $1,900 | 35 days | 35 days | |
| 1 mg | $2,730 | 35 days | 35 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Serpin A5 is a member of the human Serpin superfamily consists of at least 35 members. It is synthesized in the liver and has been detected in saliva, cerebral spinal fluid, amniotic fluid, tears and semen. As a potent inhibitor of the protein C anticoagulant pathway at the levels of both zymogen activation and enzyme inhibition, Serpin A5 additionally inhibits a variety of serine protease including thrombin, factor Xa, several kallekreins and acrosin. It plays a critical role in the processes of blood of blood coagulation and fertilization. Serpin A5 also inhibits urinary plasminogen activator (uPA), a mediator of tumor cell invasion, and regulates tumor growth and metastasis by inhibiting angiogenesis. Furthermore, recent studies have identified PCI as a potent and direct inhibitor of activated HGFA (hepatocyte growth factor activator), suggesting a novel function in the regulation of tissue repair and regeneration. Similar to Serpins C1 and D1, the thrombin inhibitory activity of serpinA5 is enhanced by heparin. |
| Species | Human |
| Expression System | HEK293 Cells |
| Tag | C-6xHis |
| Accession Number | AAH08915.1 |
| Amino Acid | His20-Pro406 |
| Construction | His20-Pro406 |
| Protein Purity | Greater than 95% as determined by reducing SDS-PAGE. (QC verified) |
| Endotoxin | < 0.1 ng/µg (1 EU/µg) as determined by LAL test. |
| Formulation | Lyophilized from a solution filtered through a 0.22 μm filter, containing 20 mM MES, 150 mM NaCl, pH 5.5. |
| Reconstitution | Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing. |
| Stability & Storage | Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
| Shipping | In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice. |
| Synonyms | SERPINA5, Serpin A5, Protein C Inhibitor, PROCI, Plasminogen Activator Inhibitor 3, Plasma Serine Protease Inhibitor, PLANH3, PCI, PAI-3, PAI3, Acrosomal Serine Protease Inhibitor |
| Research Background |
| Molecular Weight | 50-60 KDa (reducing condition) |
| Storage | Lyophilized powder: -20~-80°C for 1 year | Solution: -80°C for 6 months |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: Serpin A5 Protein, Human, Recombinant (His) chemical structure | Serpin A5 Protein, Human, Recombinant (His) molecular weight
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