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Pizuglanstat
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Catalog No. T8883Cas No. 1244967-98-3
Pizuglanstat is a hematopoietic prostaglandin synthase inhibitor.
Pizuglanstat
Copy Product Info🥰Excellent
Purity: 99.62%
Catalog No. T8883Cas No. 1244967-98-3
Pizuglanstat is a hematopoietic prostaglandin synthase inhibitor.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 5 mg | $44 | In Stock | In Stock | |
| 10 mg | $71 | In Stock | In Stock | |
| 25 mg | $161 | In Stock | In Stock | |
| 50 mg | $236 | In Stock | In Stock | |
| 100 mg | $337 | In Stock | In Stock | |
| 1 mL x 10 mM (in DMSO) | $48 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.62%
Appearance:Solid
Color:White
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Product Introduction
Pizuglanstat AI Summary
Pizuglanstat inhibits the enzyme human H-PGDS with an IC50 value of 76.0 nM in an assay involving preincubation with various concentrations of the compound and specific reaction components before adding [14C] prostaglandin H2. Additionally, it exhibited a binding affinity with recombinant human H-PGDS, with an IC50 value of 134.0 nM in a competitive fluorescence polarization assay conducted over a 1-hour incubation. The compound shows high solubility of ≥ 95000.0 nM in PBS buffer at 100 µM and pH 7.4, and has a logD of 2.25, indicating moderate lipophilicity. Its apparent permeability coefficient (Papp) at pH 7.4 is 0.21 x 10^-6 cm/s. Furthermore, Pizuglanstat demonstrates excellent metabolic stability in human liver microsomes, with 92.0% stability after 10 minutes of incubation with NADPH, and 83.0% stability after 60 minutes..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Pizuglanstat is a hematopoietic prostaglandin synthase inhibitor. |
| Molecular Weight | 508.61 |
| Formula | C27H36N6O4 |
| Cas No. | 1244967-98-3 |
| Smiles | Cn1cccc1C(=O)N1CCN(CC1)C(=O)Nc1ccc(cc1)N1CCC(CC1)C(=O)N1CCOCC1 |
| Relative Density. | 1.33 g/cm3 (Predicted) |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||
| Solubility Information | DMSO: 5.09 mg/mL (10.01 mM), Sonication is recommended.  | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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