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Chlorphenoxamine

Name: Chlorphenoxamine
Brand: TargetMol
SKU: T7564
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T7564Cas No. 77-38-3

Alias Contristamine

Chlorphenoxamine (Contristamine) is an antihistamine and anticholinergic utilized as an antipruritic and antiparkinsonian agent.

Chlorphenoxamine

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Purity: 99.85%

Catalog No. T7564Alias ContristamineCas No. 77-38-3

Chlorphenoxamine (Contristamine) is an antihistamine and anticholinergic utilized as an antipruritic and antiparkinsonian agent.

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$30	-	In Stock
5 mg	$47	-	In Stock
10 mg	$74	-	In Stock
25 mg	$108	-	In Stock
50 mg	$150	In Stock	In Stock
100 mg	$218	-	In Stock
200 mg	$323	-	In Stock
1 mL x 10 mM (in DMSO)	$57	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.85%

Appearance:Liquid

Color:Transparent

Resource Download

COA HNMR LCMS

Product Introduction

Chlorphenoxamine AI Summary

Chlorphenoxamine demonstrates inhibitory activity against the MES-SA/DX5 cell line by targeting P-glycoprotein, with an activity level of 0.91. Additionally, it exhibits antiviral properties against SARS-CoV-2 by reducing virus-induced cytotoxicity in VERO-E6 cells, with an IC50 ranging between 14454.4 nM and 19500.0 nM when exposed to 0.01 MOI of the virus for 48 hours. The compound's toxicity, indicated by a CC50 value, is 28200.0 nM in VERO-E6 cells over the same period but without virus exposure..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Chlorphenoxamine (Contristamine) is an antihistamine and anticholinergic utilized as an antipruritic and antiparkinsonian agent.
Synonyms	Contristamine

Chemical Properties

Molecular Weight	303.83
Formula	C₁₈H₂₂ClNO
Cas No.	77-38-3
Smiles	CN(C)CCOC(C)(c1ccccc1)c1ccc(Cl)cc1
Relative Density.	1.093 g/cm3 (Predicted)

Storage & Solubility Information

Storage

keep away from moisture,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (164.57 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.58 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.2913 mL	16.4566 mL	32.9131 mL	164.5657 mL
5 mM	0.6583 mL	3.2913 mL	6.5826 mL	32.9131 mL
10 mM	0.3291 mL	1.6457 mL	3.2913 mL	16.4566 mL
20 mM	0.1646 mL	0.8228 mL	1.6457 mL	8.2283 mL
50 mM	0.0658 mL	0.3291 mL	0.6583 mL	3.2913 mL
100 mM	0.0329 mL	0.1646 mL	0.3291 mL	1.6457 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc