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CDKI-73

Name: CDKI-73
Brand: TargetMol
SKU: T14919
Price: 146 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T14919 Copy Product Info

Purity: 98.11%

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CDKI-73 is a potent CDK9 inhibitor (Ki: 4 nM). It shows selective toxicity to CLL cells(LD50=80 nM) versus normal B cell and normal CD34+ cell(LD50>20 uM).The inhibition of CDK9 induces apoptosis and potentiates the effect of cisplatin.

Cas No. 1421693-22-2

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Pack Size	Price	USA Stock	Global Stock
1 mg	$146	In Stock	In Stock
2 mg	$198	In Stock	In Stock
5 mg	$308	In Stock	In Stock
10 mg	$443	In Stock	In Stock
25 mg	$732	In Stock	In Stock
50 mg	$987	In Stock	In Stock
100 mg	$1,390	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$323	In Stock	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:98.11%

Appearance:solid

Color:White

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	CDKI-73 is a potent CDK9 inhibitor (Ki: 4 nM). It shows selective toxicity to CLL cells(LD50=80 nM) versus normal B cell and normal CD34+ cell(LD50>20 uM).The inhibition of CDK9 induces apoptosis and potentiates the effect of cisplatin.
Targets & IC50	CDK6:37.68 nM, CDK1:8.17 nM, CDK7:134.26 nM, CDK2:3.27 nM, CDK4:8.18 nM, CDK9:5.78 nM
In vitro	CDKI-73, one of the most potent CDK9 inhibitors, against a panel of AML cell lines and samples derived from 97 patients.?CDKI-73 induced cancer cells undergoing apoptosis through transcriptional downregulation of anti-apoptotic proteins Bcl-2, Mcl-1 and XIAP by majorly targeting CDK9[3].
In vivo	CDKI-73 exhibited a favorable pharmacokinetic profile with oral bioavailability of F = 56% following a single intravenous bolus dose at 2 mg/kg and an oral dose at 10 mg/kg in mice [1].

Chemical Properties

Molecular Weight	394.45
Formula	C₁₅H₁₅FN₆O₂S₂
Cas No.	1421693-22-2
Smiles	CNc1nc(C)c(s1)-c1nc(Nc2cccc(c2)S(N)(=O)=O)ncc1F
Relative Density.	1.524 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 72.5 mg/mL (183.8 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 7.25 mg/mL (18.38 mM), Solution.

10% DMSO+90% Saline: < 7.25 mg/mL (18.38 mM), Lower concentrations may be soluble, but exact solubility limit is unknown.

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 2.5 mg/mL (6.34 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5352 mL	12.6759 mL	25.3518 mL	126.7588 mL
5 mM	0.5070 mL	2.5352 mL	5.0704 mL	25.3518 mL
10 mM	0.2535 mL	1.2676 mL	2.5352 mL	12.6759 mL
20 mM	0.1268 mL	0.6338 mL	1.2676 mL	6.3379 mL
50 mM	0.0507 mL	0.2535 mL	0.5070 mL	2.5352 mL
100 mM	0.0254 mL	0.1268 mL	0.2535 mL	1.2676 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc