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Anti-HCN4 Polyclonal Antibody
(Synonyms: Potassium/sodium hyperpolarization activated cyclic nucleotide gated channel 4, Hyperpolarization activated Cyclic Nucleotide-gated channel 4, Hyperpolarization activated cyclic nucleotide gated potassium channel 4, HCN 4) Copy Product Info
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Synonyms: Potassium/sodium hyperpolarization activated cyclic nucleotide gated channel 4, Hyperpolarization activated Cyclic Nucleotide-gated channel 4, Hyperpolarization activated cyclic nucleotide gated potassium channel 4, HCN 4
Catalog No. TMAB-00837 Copy Product Info
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Anti-HCN4 Polyclonal Antibody is a Rabbit antibody targeting HCN4. Anti-HCN4 Polyclonal Antibody can be used in FCM,IF,IHC-Fr,WB.
Anti-HCN4 Polyclonal Antibody
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 50 μL | $222 | 7-10 days | 7-10 days | |
| 100 μL | $373 | 7-10 days | 7-10 days | |
| 200 μL | $529 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
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| Description | Anti-HCN4 Polyclonal Antibody is a Rabbit antibody targeting HCN4. Anti-HCN4 Polyclonal Antibody can be used in FCM,IF,IHC-Fr,WB. |
| Synonyms | Potassium/sodium hyperpolarization activated cyclic nucleotide gated channel 4, Hyperpolarization activated Cyclic Nucleotide-gated channel 4, Hyperpolarization activated cyclic nucleotide gated potassium channel 4, HCN 4 |
| Ig Type | IgG |
| Reactivity | Human,Mouse,Rat (predicted:Pig,Cow,Rabbit) |
| Application | |
| Recommended Dose | WB: 1:500-2000; IHC-Fr: 1:100-500; IF: 1:100-500; FCM: 1ug/Test |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Membrane; Multi-pass membrane protein. |
| Tissue Specificity | Highly expressed in thalamus, testis and in heart, both in ventricle and atrium. Detected at much lower levels in amygdala, substantia nigra, cerebellum and hippocampus. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1 mg/mL |
| Research Background | HCN4 is a member of the family of hyperpolarization activated and cyclic nucleotide gated (HCN) channels. HCN currents have been linked to pacemaker activity in the heart and brain, resting potential control, as well as neuronal plasticity. It has been shown that HCN4 channels function as receptors for sour taste, and are associated with pacemaker potential generation in the sinoatrial node. |
| Immunogen | KLH conjugated synthetic peptide: human HCN4 |
| Antigen Species | Human |
| Gene Name | HCN4 |
| Gene ID | |
| Protein Name | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 |
| Uniprot ID | |
| Biology Area | Cardiac arrhythmias,More Channels,More Ion Channels,Taste system |
| Function | Hyperpolarization-activated ion channel with very slow activation and inactivation exhibiting weak selectivity for potassium over sodium ions. May contribute to the native pacemaker currents in heart (If) and in neurons (Ih). Activated by cAMP. May mediate responses to sour stimuli. |
| Molecular Weight | Theoretical: 129 kDa. Actual: 129 kDa. |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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