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Anti-GPRC5D Antibody (8B50)
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Catalog No. TMAY-02844
Alias GPRC5D
Anti-GPRC5D Antibody (8B50) is a Mouse antibody targeting GPRC5D. Anti-GPRC5D Antibody (8B50) can be used in ELISA,FCM.
Anti-GPRC5D Antibody (8B50)
Anti-GPRC5D Antibody (8B50)
😃Good
Catalog No. TMAY-02844Alias GPRC5D
Anti-GPRC5D Antibody (8B50) is a Mouse antibody targeting GPRC5D. Anti-GPRC5D Antibody (8B50) can be used in ELISA,FCM.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | $198 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-GPRC5D Antibody (8B50) is a Mouse antibody targeting GPRC5D. Anti-GPRC5D Antibody (8B50) can be used in ELISA,FCM. |
| Alias | GPRC5D |
| Ig Type | Monoclonal Mouse IgG2b |
| Clone | 8B50 |
| Reactivity | Human |
| Verified Activity | 1. Flow cytometric analysis of Human GPRC5D expression on CHO-K1-transfected Cells were stained with purified anti-Human GPRC5D, then a FITC-conjugated second step antibody. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells. 2. Measured by its binding ability in a functional ELISA. Immobilized Human GPRC5D-VLP protein at 5 μg/mL (100 μL/well) can bind GPRC5D Antibody, Mouse MAb, the EC50is 0.5-5 ng/mL. The VLP isotype control Protein is the negative control. |
| Application | ELISA,FCM |
| Recommended Dose | ELISA: 1:1000-1:2000; FCM: 1:25-1:100 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human GPRC5D. The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | Orphan G-protein-coupled receptor family C group 5 member D (GPRC5D) has seven transmembrane segments forming the core of the receptor, as well as an intracellular C-tail and an extracellular N-terminal domain. GPRC5D is highly and selectively expressed on the surface of CD138+ multiple myeloma (MM) cells, whereas in normal tissues, a much lower expression is limited to plasma cells and certain hard keratinizing tissues. This makes GPRC5D a promising marker for monitoring tumor load and a target antigen for MM-specific T cell-engaging therapies such as bispecific antibodies and CAR-T cells. |
| Conjucates | Unconjugated |
| Others Formats | APC/FITC/PE |
| Antibody Types Available | 4 |
| Immunogen | Recombinant Human GPRC5D Protein |
| Antigen Species | Human |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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