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Metyrosine
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Catalog No. T22368Cas No. 672-87-7
Alias α-Methyltyrosine
Metyrosine (α-Methyltyrosine) is an antihypertensive drug and could be used as a tyrosine hydroxylase inhibitor.Metyrosine significantly inhibits high COX-2 activity. Metyrosine is a very effective agent for blood pressure control.
Metyrosine
Copy Product Info🥰Excellent
Purity: 99.72%
Catalog No. T22368Alias α-MethyltyrosineCas No. 672-87-7
Metyrosine (α-Methyltyrosine) is an antihypertensive drug and could be used as a tyrosine hydroxylase inhibitor.Metyrosine significantly inhibits high COX-2 activity. Metyrosine is a very effective agent for blood pressure control.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 25 mg | $39 | In Stock | In Stock | |
| 50 mg | $55 | In Stock | In Stock | |
| 100 mg | $80 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Batch Information
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Purity:99.72%
Appearance:Solid
Color:White
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Product Introduction
Metyrosine AI Summary
Metyrosine exhibits a range of multi-target bioactivities. It shows potent inhibitory activity against numerous targets, including IMPase, Bloom's syndrome helicase (BLM), histone lysine methyltransferase G9a, human Flap endonuclease 1 (FEN1), Polymerase Iota, Marburg Virus entry, D2 Dopamine Receptor, Ebola Virus entry, and Schwann cell PMP22 intronic element. Additionally, it demonstrates significant antiviral activity against several viruses, notably inhibiting SARS-CoV-2-induced cytotoxicity in various cell lines and showing inhibitory effects against the SARS-CoV-2 3CL-Pro protease.
The compound also impacts liver function, as indicated by increased activities of liver enzymes such as alkaline phosphatase, serum glutamic oxaloacetic transaminase (SGOT), serum glutamic pyruvic transaminase (SGPT), lactate dehydrogenase (LDH), and gamma-glutamyl transferase (GGT). Despite these effects, the compound is assessed to have a low risk for drug-induced liver injury in humans.
Further, Metyrosine exhibits significant inhibition of sodium fluorescein uptake in OATP1B3- and OATP1B1-transfected CHO cells at an equimolar concentration of 10 uM. It shows minimal inhibition of human HDAC6 in enzymatic assays with custom peptide substrates and lacks notable binding affinity or inhibition towards other tested receptors/enzymes.
The synthesis of these results highlights Metyrosine's potential as a multi-target therapeutic agent, with notable antiviral properties and specific biochemical activities that warrant further investigation..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Metyrosine (α-Methyltyrosine) is an antihypertensive drug and could be used as a tyrosine hydroxylase inhibitor.Metyrosine significantly inhibits high COX-2 activity. Metyrosine is a very effective agent for blood pressure control. |
| Synonyms | α-Methyltyrosine |
| Molecular Weight | 195.22 |
| Formula | C10H13NO3 |
| Cas No. | 672-87-7 |
| Smiles | C[C@](N)(Cc1ccc(O)cc1)C(O)=O |
| Relative Density. | 1.283g/cm3 |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | H2O: < 1 mg/mL (insoluble)  DMSO: < 1 mg/mL (insoluble or slightly soluble) |
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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