Shopping Cart

Your shopping cart is currently empty

RA190

Name: RA190
Brand: TargetMol
SKU: T13858
Price: 52 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T13858Cas No. 1617495-03-0

RA190 inhibits proteasome function by covalently binding to cysteine 88 of ubiquitin receptor RPN13.

RA190

🥰Excellent

Purity: 97.7%

Catalog No. T13858Cas No. 1617495-03-0

RA190 inhibits proteasome function by covalently binding to cysteine 88 of ubiquitin receptor RPN13.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$52	In Stock	In Stock
5 mg	$117	In Stock	In Stock
10 mg	$171	In Stock	In Stock
25 mg	$258	In Stock	In Stock
50 mg	$460	-	In Stock
100 mg	$676	-	In Stock
1 mL x 10 mM (in DMSO)	$153	In Stock	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:97.7%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	RA190 inhibits proteasome function by covalently binding to cysteine 88 of ubiquitin receptor RPN13.
Targets&IC50	HeLa cells:0.15 μM
In vitro	Multiple myeloma (MM) lines, even those resistant to bortezomib, are sensitive to RA190 via endoplasmic reticulum stress-related apoptosis. RA190 stabilizes targets of human papillomavirus (HPV) E6 oncoprotein, and preferentially kills HPV-transformed cells.
In vivo	RA190 administration profoundly reduces growth of multiple myeloma and ovarian cancer xenografts, and oral RA190 treatment retards HPV16+ syngeneic mouse tumor growth, without impacting spontaneous HPV-specific CD8+ T cell responses.

Chemical Properties

Molecular Weight	596.76
Formula	C₂₈H₂₃Cl₅N₂O₂
Cas No.	1617495-03-0
Smiles	Cl.N[C@@H](Cc1ccccc1)C(=O)N1C\C(=C\c2ccc(Cl)c(Cl)c2)C(=O)\C(C1)=C/c1ccc(Cl)c(Cl)c1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 95 mg/mL (159.19 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (5.53 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.6757 mL	8.3786 mL	16.7572 mL	83.7858 mL
5 mM	0.3351 mL	1.6757 mL	3.3514 mL	16.7572 mL
10 mM	0.1676 mL	0.8379 mL	1.6757 mL	8.3786 mL
20 mM	0.0838 mL	0.4189 mL	0.8379 mL	4.1893 mL
50 mM	0.0335 mL	0.1676 mL	0.3351 mL	1.6757 mL
100 mM	0.0168 mL	0.0838 mL	0.1676 mL	0.8379 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc