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WT-161

Name: WT-161
Brand: TargetMol
SKU: T7385
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T7385Cas No. 1206731-57-8

WT161 is a potent and selective inhibitor of HDAC6 (IC50:0.40 nM).

WT-161

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Purity: 98.34%

Catalog No. T7385Cas No. 1206731-57-8

WT161 is a potent and selective inhibitor of HDAC6 (IC50:0.40 nM).

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$30	In Stock	In Stock
5 mg	$64	In Stock	In Stock
10 mg	$106	In Stock	In Stock
25 mg	$196	In Stock	In Stock
50 mg	$297	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$85	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:98.34%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	WT161 is a potent and selective inhibitor of HDAC6 (IC50:0.40 nM).
Targets&IC50	HDAC6:0.40 nM, HDAC8:1430 nM, HDAC1:8.35 nM, HDAC3:51.6 nM, HDAC2:15.4 nM
In vitro	Treatment of anti-multiple myeloma (MM) cell lines with WT161 triggers the accumulation of acetylated tubulin and cell death in MM cell lines more potently than tubacin. Additionally, WT161 in combination with BTZ induces synergistic cytotoxicity and overcomes BTZ resistance in vitro[1].
In vivo	WT161 significantly inhibits in vivo MCF7 cell growth, associated with downregulation of ERα, in a murine xenograft model[2].
Animal Research	Female NCr nu/nu mice were subcutaneously (sc) implanted with 17?-estradiol-sustained release pellets (0.18 mg, 60 day release time). Mice were inoculated sc with 5 × 10^6 MCF-7 cells suspended in 30% Matrigel. After 1 month of growth, mice with measurable tumors (> 50 mm^3) were assigned into cohorts receiving intraperitoneal WT161 daily (80 mg/kg) or into a control group receiving vehicle alone (10% DMSO, 90% PBS). Caliper measurements of the longest perpendicular tumor diameters were performed every alternate day to estimate the tumor volume, using the formula volume = ? x L x W^2. Animals were sacrificed when tumors reached 2 cm or if the mice appeared moribund. For each animal, relative tumor volume was determined by normalizing data to the baseline tumor volume for that animal at the start of treatment. Statistical significance was determined by 2-way ANOVA analysis[2].

Chemical Properties

Molecular Weight	458.55
Formula	C₂₇H₃₀N₄O₃
Cas No.	1206731-57-8
Smiles	N(C1=CC=C(C=NNC(CCCCCCC(NO)=O)=O)C=C1)(C2=CC=CC=C2)C3=CC=CC=C3
Relative Density.	1.15 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (218.08 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (8.72 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1808 mL	10.9039 mL	21.8079 mL	109.0394 mL
5 mM	0.4362 mL	2.1808 mL	4.3616 mL	21.8079 mL
10 mM	0.2181 mL	1.0904 mL	2.1808 mL	10.9039 mL
20 mM	0.1090 mL	0.5452 mL	1.0904 mL	5.4520 mL
50 mM	0.0436 mL	0.2181 mL	0.4362 mL	2.1808 mL
100 mM	0.0218 mL	0.1090 mL	0.2181 mL	1.0904 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc