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Anti-Phospho-HDAC4/5/9 (Ser246/259/220) Polyclonal Antibody

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Catalog No. TMAC-01780

Anti-Phospho-HDAC4/5/9 (Ser246/259/220) Polyclonal Antibody is a Rabbit antibody targeting Phospho-HDAC4/5/9 (Ser246/259/220). Anti-Phospho-HDAC4/5/9 (Ser246/259/220) Polyclonal Antibody can be used in WB,IHC.

Anti-Phospho-HDAC4/5/9 (Ser246/259/220) Polyclonal Antibody

Anti-Phospho-HDAC4/5/9 (Ser246/259/220) Polyclonal Antibody

😃Good
Catalog No. TMAC-01780
Anti-Phospho-HDAC4/5/9 (Ser246/259/220) Polyclonal Antibody is a Rabbit antibody targeting Phospho-HDAC4/5/9 (Ser246/259/220). Anti-Phospho-HDAC4/5/9 (Ser246/259/220) Polyclonal Antibody can be used in WB,IHC.
Pack SizePriceAvailabilityQuantity
50 μL$2187-10 days
100 μL$3177-10 days
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Product Introduction

Bioactivity
Description
Anti-Phospho-HDAC4/5/9 (Ser246/259/220) Polyclonal Antibody is a Rabbit antibody targeting Phospho-HDAC4/5/9 (Ser246/259/220). Anti-Phospho-HDAC4/5/9 (Ser246/259/220) Polyclonal Antibody can be used in WB,IHC.
Ig Type
IgG
Reactivity
Human
Application
Antibody Type
Polyclonal
Host SpeciesRabbit
ConstructionPolyclonal Antibody
PurificationAntibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
AppearanceLiquid
FormulationSupplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Research BackgroundHistone Deacetylases (HDACs) are a group of enzymes closely related to sirtuins. They catalyze the removal of acetyl groups from lysine residues in histones and non-histone proteins, resulting in transcriptional repression. In general,they do not act autonomously but as components of large multiprotein complexes, such as pRb-E2F and mSin3A, that mediate important transcription regulatory pathways. There are three classes of HDACs; classes 1, 2 and 4, which are closely related Zn2+-dependent enzymes. HDACs are ubiquitously expressed and they can exist in the nucleus or cytosol. Their subcellular localization is effected by protein-protein interactions (for example HDAC-14.3.3 complexes are retained in the cytosol) and by the class to which they belong (class 1 HDACs are predominantly nuclear whilst class 2 HDACs shuttle between the nucleus and cytosol). HDACs have a role in cell growth arrest, differentiation and death and this has led to substantial interest in HDAC inhibitors as possible antineoplastic agents.
Related Conjugates and Formulations
Conjucates
Unconjugated
Others Formats
Phospho
Antigen Details
Immunogen
Peptide sequence around phosphorylation site of serine 246/259/220 (T-A-S(p)-EP) derived from Human HDAC4/HDAC5/HDAC9
Antigen Species
human
Chemical Properties
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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