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CCCI-01

Name: CCCI-01
Brand: TargetMol
SKU: T25212
Price: 37 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T25212Cas No. 215778-97-5

Alias Centrosome Clustering Chemical Inhibitor-01, CCCI01, CCCI 01

CCCI-01(Centrosome Clustering Chemical Inhibitor-01) is a centrosome cluster inhibitor. CCCI-01 has anticancer activity, induces apoptosis, and can be used in the study of non-cross-resistant anticancer compounds that block centrosome clustering.

CCCI-01

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Purity: 99.97%

Catalog No. T25212Alias Centrosome Clustering Chemical Inhibitor-01, CCCI01, CCCI 01Cas No. 215778-97-5

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$37	-	In Stock
10 mg	$57	-	In Stock
25 mg	$113	-	In Stock
50 mg	$167	-	In Stock
100 mg	$251	-	In Stock
200 mg	$343	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.97%

Appearance:Solid

Color:Yellow

Resource Download

COA HNMR LCMS

Product Introduction

CCCI-01 AI Summary

CCCI-01 exhibits a variety of bioactivities. It is a splicing modulator of Lamin A with a potency of 19952.6 nM and increases expression of NF-kB in human neuronal cells with an EC50 of 2811.0 nM. The compound demonstrates cytotoxic activity on NIH3T3 cells with an EC50 greater than 60000.0 nM. Importantly, it acts as an inhibitor of Trypanosoma cruzi infection with an EC50 of 137.0 nM and inhibits replication with an EC50 of less than 100.0 nM. Additionally, CCCI-01 inhibits Schistosoma mansoni Peroxiredoxins with a potency of 44668.4 nM and shows various potencies in inhibiting different targets related to malarial parasites, DNA re-replication, histone interactions, and other biological processes, with values ranging from approximately 1000 nM to 100000 nM..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	CCCI-01(Centrosome Clustering Chemical Inhibitor-01) is a centrosome cluster inhibitor. CCCI-01 has anticancer activity, induces apoptosis, and can be used in the study of non-cross-resistant anticancer compounds that block centrosome clustering.
Synonyms	Centrosome Clustering Chemical Inhibitor-01, CCCI01, CCCI 01

Chemical Properties

Molecular Weight	247.21
Formula	C₁₁H₉N₃O₄
Cas No.	215778-97-5
Smiles	C(NCC=1C=CC=NC1)(=O)C=2OC(N(=O)=O)=CC2
Relative Density.	no data available

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (222.48 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (8.09 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.0451 mL	20.2257 mL	40.4514 mL	202.2572 mL
5 mM	0.8090 mL	4.0451 mL	8.0903 mL	40.4514 mL
10 mM	0.4045 mL	2.0226 mL	4.0451 mL	20.2257 mL
20 mM	0.2023 mL	1.0113 mL	2.0226 mL	10.1129 mL
50 mM	0.0809 mL	0.4045 mL	0.8090 mL	4.0451 mL
100 mM	0.0405 mL	0.2023 mL	0.4045 mL	2.0226 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc