Powder: -20°C for 3 years | In solvent: -80°C for 1 year
HS-291 is a HtpG inhibitor targeting Borrelia burgdorferi (Bb), composed of BX-2819 (high affinity for Bb HtpG), a PEG linker, and Verteporfin (a photoactive toxin). Upon light activation, HS-291 generates reactive oxygen species that oxidize HtpG and selectively inactivate a subset of proteins in proximity to chaperones, facilitating the rapid and irreversible inactivation of Bb [1].
Pack Size | Availability | Price/USD | Quantity |
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5 mg | Inquiry | Inquiry | |
50 mg | Inquiry | Inquiry |
Description | HS-291 is a HtpG inhibitor targeting Borrelia burgdorferi (Bb), composed of BX-2819 (high affinity for Bb HtpG), a PEG linker, and Verteporfin (a photoactive toxin). Upon light activation, HS-291 generates reactive oxygen species that oxidize HtpG and selectively inactivate a subset of proteins in proximity to chaperones, facilitating the rapid and irreversible inactivation of Bb [1]. |
In vitro | HS-291, at concentrations ranging from 0.1 to 10 μM and with a 24-hour treatment period, suppresses the cultured activity of Bb when excited by near-infrared radiation (nrIR) at an excitation (Ex) wavelength of 693 nm and an energy density of 5 J/cm² [1]. |
Molecular Weight | N/A |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
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HS-291 Tyrosine Kinase/Adaptors ROS Kinase inhibitor inhibit