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Iopromide

Name: Iopromide
Brand: TargetMol
SKU: T1522
Price: 33 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1522Cas No. 73334-07-3

Alias Ultravist, Iopromidum

Iopromide (Iopromidum) is a low osmolar, non-ionic contrast agent for intravascular use.

Iopromide

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Purity: 98.84%

Catalog No. T1522Alias Ultravist, IopromidumCas No. 73334-07-3

Iopromide (Iopromidum) is a low osmolar, non-ionic contrast agent for intravascular use.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$33	In Stock	In Stock
10 mg	$46	In Stock	In Stock
25 mg	$79	In Stock	In Stock
50 mg	$108	In Stock	In Stock
100 mg	$147	In Stock	In Stock
500 mg	$368	Inquiry	Inquiry
1 mL x 10 mM (in DMSO)	$40	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:98.84%

Color:White

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COA HNMR LCMS

Product Introduction

Iopromide AI Summary

Iopromide demonstrates a comprehensive clearance profile in humans with a total body clearance rate of 1.4 mL.min^-1.kg^-1 and a renal clearance rate of 1.37 mL.min^-1.kg^-1, indicating efficient excretion both generally and via the kidneys. It has a volume of distribution at steady state of 0.22 L.kg^-1 and a high fraction unbound at 0.99, along with a mean residence time and half-life of 2.6 hours. The compound exhibits hepatotoxicity markers, with a score of 1.0 for acute and cytolytic liver toxicity, although no severe hepatic side effects were noted by the Drug Induced Liver Injury Prediction System (DILIps). Bioactivity-wise, Iopromide interacts with various liver enzymes and demonstrates inhibitory activity against several protein complexes, notably the RanGTP-induced and USP1/UAF1 complexes, with nanomolar potency. It also blocks Ebola virus entry with AC50 values in the micromolar to nanomolar range, suggesting potential as an antiviral agent. For SARS-CoV-2, it shows limited efficacy at a concentration of 10 μM, with IC50 values indicating weak antiviral potency. Lastly, it inhibits human HDAC6 activity with observed inhibition percentages of 28.85% and 1.62% using different peptide substrates. These characteristics highlight Iopromide's versatile bioactivity profile and potential therapeutic applications..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Iopromide (Iopromidum) is a low osmolar, non-ionic contrast agent for intravascular use.
Synonyms	Ultravist, Iopromidum

Chemical Properties

Molecular Weight	791.11
Formula	C₁₈H₂₄I₃N₃O₈
Cas No.	73334-07-3
Smiles	COCC(=O)Nc1c(I)c(C(=O)NCC(O)CO)c(I)c(C(=O)N(C)CC(O)CO)c1I
Relative Density.	2.173 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (316.01 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (4.17 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.2640 mL	6.3202 mL	12.6405 mL	63.2023 mL
5 mM	0.2528 mL	1.2640 mL	2.5281 mL	12.6405 mL
10 mM	0.1264 mL	0.6320 mL	1.2640 mL	6.3202 mL
20 mM	0.0632 mL	0.3160 mL	0.6320 mL	3.1601 mL
50 mM	0.0253 mL	0.1264 mL	0.2528 mL	1.2640 mL
100 mM	0.0126 mL	0.0632 mL	0.1264 mL	0.6320 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc