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Anti-KLHDC2 Polyclonal Antibody

Catalog No. TMAB-08099 Copy Product Info
🥰Excellent
Anti-KLHDC2 Polyclonal Antibody is a Rabbit antibody targeting KLHDC2. Anti-KLHDC2 Polyclonal Antibody can be used in WB.

Anti-KLHDC2 Polyclonal Antibody

Copy Product Info
🥰Excellent
Catalog No. TMAB-08099

Anti-KLHDC2 Polyclonal Antibody is a Rabbit antibody targeting KLHDC2. Anti-KLHDC2 Polyclonal Antibody can be used in WB.

Anti-KLHDC2 Polyclonal Antibody
Pack SizePriceUSA StockGlobal StockQuantity
50 μL$2207-10 days7-10 days
100 μL$3737-10 days7-10 days
200 μL$5277-10 days7-10 days
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction

Bioactivity
Description
Anti-KLHDC2 Polyclonal Antibody is a Rabbit antibody targeting KLHDC2. Anti-KLHDC2 Polyclonal Antibody can be used in WB.
Ig Type
IgG
Reactivity
Mouse (predicted:Human,Rat,Cow,Horse,Rabbit,Sheep)
Verified Activity
Sample: Tongue (Mouse) Lysate at 40 μg
Primary: Anti-KLHDC2 (TMAB-08099) at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 46 kD
Observed band size: 43 kD
Application
Recommended Dose
WB: 1:500-2000
Antibody Type
Polyclonal
Host SpeciesRabbit
Subcellular LocalizationNucleus.
Tissue SpecificityWidely expressed, with high levels in skeletal muscle, heart, pancreas and liver. Undetectable in peripheral blood leukocytes.
ConstructionPolyclonal Antibody
PurificationProtein A purified
AppearanceLiquid
Formulation0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Concentration1mg/ml
Research BackgroundKLHDC2 is a 406 amino acid protein that contains six kelch repeats. Localizing to the nucleus, KLHDC2 is widely expressed, with high levels found in muscle, heart, pancreas and liver. KLHDC2 interacts directly with CREB3, repressing CREB3-mediated transcription. Existing as two alternatively spliced isoforms, the gene encoding KLHDC2 maps to human chromosome 14, which houses over 700 genes and comprises nearly 3.5% of the human genome. Chromosome 14 encodes the presinilin 1 (PSEN1) gene, which is one of the three key genes associated with the development of Alzheimer's disease (AD). The SERPINA1 gene is also located on chromosome 14 and, when defective, leads to the genetic disorder ?-antitrypsin deficiency, which is characterized by severe lung complications and liver dysfunction.
Antigen Details
Immunogen
KLH conjugated synthetic peptide: human KLHDC2
Antigen Species
Human
Gene Name
KLHDC2
Gene ID
Protein Name
Kelch domain-containing protein 2
Uniprot ID
Function
Represses CREB3-mediated transcription by interfering with CREB3-DNA binding.
Chemical Properties
Molecular WeightTheoretical: 46 kDa.
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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