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Kynurenic acid

Catalog No. T65135 CAS 492-27-3

Synonyms: Fibrostop 2, Quinurenic acid

Kynurenic acid (Quinurenic acid) is an endogenous tryptophan active metabolite, a triple antagonist of NMDA, glutamate, α7 nicotinic acetylcholine receptor, and an agonist of GPR35/CXCR8 with neuroprotective and anticonvulsant properties. It has neuroprotective and anticonvulsant properties and can be used to study neurodegeneration and metabolism-related diseases.

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Kynurenic acid, CAS 492-27-3

Pack Size	Availability	Price/USD
50 mg	In stock	$ 31.00
100 mg	In stock	$ 42.00
500 mg	In stock	$ 62.00
1 g	In stock	$ 90.00

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Purity: 99.69%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Synonyms	Fibrostop 2, Quinurenic acid
Molecular Weight	189.17
Formula	C10H7NO3
CAS No.	492-27-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: <0.1 mg/mL (insoluble)

DMSO: 12.5 mg/mL (66.07 mM), Sonication is recommended.

References and Literature

1. Wang J, et al. Kynurenic acid as a ligand for orphan G protein-coupled receptor GPR35. J Biol Chem. 2006 Aug 4;281(31):22021-8. 2. Albuquerque EX, et al. Kynurenic acid as an antagonist of α7 nicotinic acetylcholine receptors in the brain: facts and challenges. Biochem Pharmacol. 2013 Apr 15;85(8):1027-32. 3. Małaczewska J, et al. Effect of oral administration of kynurenic acid on the activity of the peripheral blood leukocytes in mice. Cent Eur J Immunol. 2014;39(1):6-13.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Kynurenic acid 492-27-3 Endocrinology/Hormones GPCR/G Protein Neuroscience GPR NMDAR GluR Fibrostop 2 Quinurenic acid inhibitor inhibit

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