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Anti-DSG3 Antibody
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Catalog No. T9901A-1324
Anti-DSG3 Antibody is a highly specialized monoclonal antibody target the human desmoglein 3 protein, a critical cadherin-type cell adhesion molecule, inhibition of intercellular junctions between keratinocytes across various preclinical experimental models to modulate epithelial integrity and study the pathophysiology of pemphigus vulgaris.
Anti-DSG3 Antibody
Anti-DSG3 Antibody
Copy Product Info🥰Excellent
Catalog No. T9901A-1324
Anti-DSG3 Antibody is a highly specialized monoclonal antibody target the human desmoglein 3 protein, a critical cadherin-type cell adhesion molecule, inhibition of intercellular junctions between keratinocytes across various preclinical experimental models to modulate epithelial integrity and study the pathophysiology of pemphigus vulgaris.
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| Description | Anti-DSG3 Antibody is a highly specialized monoclonal antibody target the human desmoglein 3 protein, a critical cadherin-type cell adhesion molecule, inhibition of intercellular junctions between keratinocytes across various preclinical experimental models to modulate epithelial integrity and study the pathophysiology of pemphigus vulgaris. |
| In vitro | In keratinocyte dissociation assays, Anti-DSG3 Antibody disrupted cell-cell adhesion and induced desmoglein 3 internalization, leading to monolayer fragmentation [1]. |
| In vivo | In neonatal mouse models, systemic administration of Anti-DSG3 Antibody induced suprabasal blisters replicating the pemphigus vulgaris phenotype [1]. |
| Reactivity | Human |
| Application | FACS Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Uniprot ID | |
| Target | DSG3 |
| Isotype | IgG1 |
| Storage | store at low temperature | store at -20°C | Shipping with blue ice/Shipping at ambient temperature. |
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