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Carebastine

Name: Carebastine
Brand: TargetMol
SKU: T10680
Price: 37 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T10680Cas No. 90729-42-3

Carebastine, the active metabolite of Ebastine, is an antagonist of the histamine H1 receptor.

Carebastine

🥰Excellent

Purity: 99.16%

Catalog No. T10680Cas No. 90729-42-3

Carebastine, the active metabolite of Ebastine, is an antagonist of the histamine H1 receptor.

Pack Size	Price	Availability
2 mg	$37	In Stock
5 mg	$59	In Stock
10 mg	$97	In Stock
25 mg	$197	In Stock
50 mg	$293	In Stock
100 mg	$437	In Stock

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Purity:99.16%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	Carebastine, the active metabolite of Ebastine, is an antagonist of the histamine H1 receptor.
In vitro	Carebastine inhibits VEGF-induced HPAEC and HUVEC proliferation, migration, and angiogenesis in a dose-dependent manner [1]. Carebastine suppresses the expression of macrophage migration inhibitory factor [2].

Chemical Properties

Molecular Weight	499.64
Formula	C₃₂H₃₇NO₄
Cas No.	90729-42-3
Smiles	CC(C)(C(O)=O)c1ccc(cc1)C(=O)CCCN1CCC(CC1)OC(c1ccccc1)c1ccccc1
Relative Density.	1.18g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 1 mg/mL (2.00 mM), Sonication and heating are recommended.

DMF: 24 mg/mL (48.03 mM), Sonication and heating are recommended.

Solution Preparation Table

DMSO/DMF

	1mg	5mg	10mg	50mg
1 mM	2.0014 mL	10.0072 mL	20.0144 mL	100.0721 mL

DMF

	1mg	5mg	10mg	50mg
5 mM	0.4003 mL	2.0014 mL	4.0029 mL	20.0144 mL
10 mM	0.2001 mL	1.0007 mL	2.0014 mL	10.0072 mL
20 mM	0.1001 mL	0.5004 mL	1.0007 mL	5.0036 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc