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Moxisylyte hydrochloride

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Catalog No. T0394Cas No. 964-52-3
Alias Thymoxamine hydrochloride

Moxisylyte hydrochloride (Thymoxamine hydrochloride) is an alpha-adrenergic blocking agent that is used in Raynaud's disease.

Moxisylyte hydrochloride
Other Forms of Moxisylyte hydrochloride:
MoxisylyteT6912754-32-0
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Moxisylyte hydrochloride

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Purity: 99.94%
Catalog No. T0394Alias Thymoxamine hydrochlorideCas No. 964-52-3
Moxisylyte hydrochloride (Thymoxamine hydrochloride) is an alpha-adrenergic blocking agent that is used in Raynaud's disease.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
50 mg$36In StockIn Stock
100 mg$50In StockIn Stock
1 mL x 10 mM (in DMSO)$47In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.94%
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COA HNMR LCMS

Product Introduction

Bioactivity
Description
Moxisylyte hydrochloride (Thymoxamine hydrochloride) is an alpha-adrenergic blocking agent that is used in Raynaud's disease.
Kinase Assay
Aromatase inhibition is measured using human placental microsomes and the method of Thompson and Siiteri with Testosterone (0.5 μM) as substrate. 11-hydroxylase inhibition is determined by measuring the conversion of [1,2,6,7-3H]-ll-deoxy- cortisol to cortisol using freshly prepared mitochondria from guinea pig, dog and cow adrenal glands. Reaction products are extracted into chloroform and separated by thin layer chromatography[1].
SynonymsThymoxamine hydrochloride
Chemical Properties
Molecular Weight315.84
FormulaC16H26ClNO3
Cas No.964-52-3
SmilesCl.CC(C)c1cc(OC(C)=O)c(C)cc1OCCN(C)C
Relative Density.1.018g/cm3
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 25 mg/mL (79.15 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.33 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.1662 mL15.8308 mL31.6616 mL158.3080 mL
5 mM0.6332 mL3.1662 mL6.3323 mL31.6616 mL
10 mM0.3166 mL1.5831 mL3.1662 mL15.8308 mL
20 mM0.1583 mL0.7915 mL1.5831 mL7.9154 mL
50 mM0.0633 mL0.3166 mL0.6332 mL3.1662 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Thymoxamine HydrochlorideThymoxamineMoxisylyte HydrochlorideMoxisylyte hydrochlorideMoxisylyteInhibitorinhibitBeta ReceptorAdrenergicReceptorAdrenergic Receptor
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