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Moxisylyte hydrochloride

Name: Moxisylyte hydrochloride
Brand: TargetMol
SKU: T0394
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0394Cas No. 964-52-3

Alias Thymoxamine hydrochloride

Moxisylyte hydrochloride (Thymoxamine hydrochloride) is an alpha-adrenergic blocking agent that is used in Raynaud's disease.

Moxisylyte hydrochloride

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Purity: 99.94%

Catalog No. T0394Alias Thymoxamine hydrochlorideCas No. 964-52-3

Moxisylyte hydrochloride (Thymoxamine hydrochloride) is an alpha-adrenergic blocking agent that is used in Raynaud's disease.

Pack Size	Price	USA Warehouse	Global Warehouse
50 mg	$31	In Stock	In Stock
100 mg	$50	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.94%

Appearance:Solid

Color:White to Yellow

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	Moxisylyte hydrochloride (Thymoxamine hydrochloride) is an alpha-adrenergic blocking agent that is used in Raynaud's disease.
Kinase Assay	Aromatase inhibition is measured using human placental microsomes and the method of Thompson and Siiteri with Testosterone (0.5 μM) as substrate. 11-hydroxylase inhibition is determined by measuring the conversion of [1,2,6,7-3H]-ll-deoxy- cortisol to cortisol using freshly prepared mitochondria from guinea pig, dog and cow adrenal glands. Reaction products are extracted into chloroform and separated by thin layer chromatography[1].
Synonyms	Thymoxamine hydrochloride

Chemical Properties

Molecular Weight	315.84
Formula	C₁₆H₂₆ClNO₃
Cas No.	964-52-3
Smiles	Cl.CC(C)c1cc(OC(C)=O)c(C)cc1OCCN(C)C
Relative Density.	1.018g/cm3

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 25 mg/mL (79.15 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.33 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1662 mL	15.8308 mL	31.6616 mL	158.3080 mL
5 mM	0.6332 mL	3.1662 mL	6.3323 mL	31.6616 mL
10 mM	0.3166 mL	1.5831 mL	3.1662 mL	15.8308 mL
20 mM	0.1583 mL	0.7915 mL	1.5831 mL	7.9154 mL
50 mM	0.0633 mL	0.3166 mL	0.6332 mL	3.1662 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc