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Anti-Alpha-synuclein Antibody (4T50)
Catalog No. TMAB-02493 Copy Product Info
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Anti-Alpha-synuclein Antibody (4T50) is a Rabbit antibody targeting Alpha-synuclein. Anti-Alpha-synuclein Antibody (4T50) can be used in WB.
Anti-Alpha-synuclein Antibody (4T50)
Copy Product Info🥰Excellent
Catalog No. TMAB-02493
Anti-Alpha-synuclein Antibody (4T50) is a Rabbit antibody targeting Alpha-synuclein. Anti-Alpha-synuclein Antibody (4T50) can be used in WB.
Anti-Alpha-synuclein Antibody
(4T50)
(4T50)
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 25 μL | $151 | 7-10 days | 7-10 days | |
| 50 μL | $262 | 7-10 days | 7-10 days | |
| 100 μL | $473 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
Stability & Storage
| Description | Anti-Alpha-synuclein Antibody (4T50) is a Rabbit antibody targeting Alpha-synuclein. Anti-Alpha-synuclein Antibody (4T50) can be used in WB. |
| Ig Type | IgG |
| Clone | 4T50 |
| Reactivity | Rat,Mouse,Human |
| Verified Activity | 25 μg total protein per lane of various lysates (see on figure) probed with Alpha-synuclein monoclonal antibody, unconjugated (TMAB-02493) at 1:1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at r. T. for 60 min. |
| Application | |
| Recommended Dose | WB: 1:500-2000 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Subcellular Localization | Cytoplasm. Membrane. Nucleus. Cell junction, synapse. Note=Membrane-bound in dopaminergic neurons. |
| Tissue Specificity | Expressed principally in brain but is also expressed in low concentrations in all tissues examined except in liver. Concentrated in presynaptic nerve terminals. |
| Construction | Recombinant Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Alternatively spliced transcripts encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2016]. |
| Immunogen | Recombinant Protein: human Alpha-synuclein |
| Antigen Species | Human |
| Gene Name | SNCA |
| Gene ID | |
| Protein Name | alpha-synuclein |
| Uniprot ID | |
| Function | May be involved in the regulation of dopamine release and transport. Induces fibrillization of microtubule-associated protein tau. Reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase-3 activation. |
| Molecular Weight | Theoretical: 14 kDa. |
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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