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ERGi-USU

Name: ERGi-USU
Brand: TargetMol
SKU: T7145
Price: 41 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T7145Cas No. 1147-56-4

NSC-139021 (ERGi-USU) is a Rio2 kinase (RIOK2) inhibitor that inhibits ERG protein.

ERGi-USU

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Purity: 99.28%

Catalog No. T7145Cas No. 1147-56-4

NSC-139021 (ERGi-USU) is a Rio2 kinase (RIOK2) inhibitor that inhibits ERG protein.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
100 mg	$41	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$45	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.28%

Appearance:Solid

Color:Red

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	NSC-139021 (ERGi-USU) is a Rio2 kinase (RIOK2) inhibitor that inhibits ERG protein.
Targets&IC50	ERG (positive cancer cells):30 to 400 nM (IC50)
In vitro	ERGi-USU selectively inhibits growth of ERGpositive cancer cell lines with minimal effect on normal prostate or endothelial cells or ERG-negative tumor cell lines.?The IC50 of ERGi-USU for cell growth inhibition of responsive cell lines range between 30 nM to 400 nM[1].

Chemical Properties

Molecular Weight	255.3
Formula	C₁₃H₉N₃OS
Cas No.	1147-56-4
Smiles	Oc1ccc2ccccc2c1N=Nc1nccs1
Relative Density.	1.4g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 62 mg/mL (242.85 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (7.83 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.9170 mL	19.5848 mL	39.1696 mL	195.8480 mL
5 mM	0.7834 mL	3.9170 mL	7.8339 mL	39.1696 mL
10 mM	0.3917 mL	1.9585 mL	3.9170 mL	19.5848 mL
20 mM	0.1958 mL	0.9792 mL	1.9585 mL	9.7924 mL
50 mM	0.0783 mL	0.3917 mL	0.7834 mL	3.9170 mL
100 mM	0.0392 mL	0.1958 mL	0.3917 mL	1.9585 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc