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ERGi-USU

Name: ERGi-USU
Brand: TargetMol
SKU: T7145
Price: 41 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T7145Cas No. 1147-56-4

NSC-139021 (ERGi-USU) is a Rio2 kinase (RIOK2) inhibitor that inhibits ERG protein.

ERGi-USU

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Purity: 99.28%

Catalog No. T7145Cas No. 1147-56-4

NSC-139021 (ERGi-USU) is a Rio2 kinase (RIOK2) inhibitor that inhibits ERG protein.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
100 mg	$41	-	In Stock
1 mL x 10 mM (in DMSO)	$45	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.28%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	NSC-139021 (ERGi-USU) is a Rio2 kinase (RIOK2) inhibitor that inhibits ERG protein.
Targets&IC50	ERG (positive cancer cells):30 to 400 nM (IC50)
In vitro	ERGi-USU selectively inhibits growth of ERGpositive cancer cell lines with minimal effect on normal prostate or endothelial cells or ERG-negative tumor cell lines.?The IC50 of ERGi-USU for cell growth inhibition of responsive cell lines range between 30 nM to 400 nM[1].

Chemical Properties

Molecular Weight	255.3
Formula	C₁₃H₉N₃OS
Cas No.	1147-56-4
Smiles	Oc1ccc2ccccc2c1N=Nc1nccs1
Relative Density.	1.4g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 62 mg/mL (242.85 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (7.83 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.9170 mL	19.5848 mL	39.1696 mL	195.8480 mL
5 mM	0.7834 mL	3.9170 mL	7.8339 mL	39.1696 mL
10 mM	0.3917 mL	1.9585 mL	3.9170 mL	19.5848 mL
20 mM	0.1958 mL	0.9792 mL	1.9585 mL	9.7924 mL
50 mM	0.0783 mL	0.3917 mL	0.7834 mL	3.9170 mL
100 mM	0.0392 mL	0.1958 mL	0.3917 mL	1.9585 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc