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Succimer

Name: Succimer
Brand: TargetMol
SKU: T2552
Price: 40 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2552Cas No. 304-55-2

Alias meso-2,3-dimercaptosuccinic acid, DMSA, Dimercaptosuccinic acid

Succimer (Dimercaptosuccinic acid) is a Lead Chelator. The mechanism of action of succimer is as a Lead Chelating Activity.

Succimer

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Purity: 99.8%

Catalog No. T2552Alias meso-2,3-dimercaptosuccinic acid, DMSA, Dimercaptosuccinic acidCas No. 304-55-2

Succimer (Dimercaptosuccinic acid) is a Lead Chelator. The mechanism of action of succimer is as a Lead Chelating Activity.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
500 mg	$40	-	In Stock
1 g	$56	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.8%

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Succimer AI Summary

Succimer exhibits noteworthy bioactivity and pharmacological properties across several domains. It shows significant inhibitory activity against the SARS-CoV-2 3CL-Pro protease, with inhibition percentages ranging from 97.72% to 98.97% at a 20 µM concentration and varying IC50 values reported (6.743 µM and 0.0836 µM for different substrates). Additionally, it demonstrates antiviral activity by reducing cytotoxicity in Caco-2 and VERO-6 cells in response to SARS-CoV-2 at a concentration of 10 µM. The compound also inhibits Escherichia coli chaperone proteins GroEL and GroES, impacting protein folding activities. On the other hand, Succimer is associated with moderate liver toxicity, indicated by elevated liver enzymes such as ALT, AST, alkaline phosphatase, SGOT, SGPT, LDH, and GGT. However, it does not cause acute liver toxicity or specific types of hepatotoxicity like cytolytic or cholestatic injury, nor does it lead to severe liver conditions like hepatitis, cirrhosis, or tumors. Clinical trials indicate a moderate prevalence (56.7%) of hepatotoxicity. In terms of its effects on human HDAC6, Succimer shows modest inhibition with percentages of 28.73% and 2.09% in enzymatic assays using different substrates. It does not exhibit significant bioactivity against an array of human and rat receptors and enzymes, with AC50 values consistently above 30000.0 nM. Additionally, it has been documented to have a severity class index of 2.0 for drug-induced liver injury in humans. Overall, Succimer's profile suggests potential as an antiviral agent against SARS-CoV-2, albeit with considerations for its moderate hepatotoxicity..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Succimer (Dimercaptosuccinic acid) is a Lead Chelator. The mechanism of action of succimer is as a Lead Chelating Activity.
Synonyms	meso-2,3-dimercaptosuccinic acid, DMSA, Dimercaptosuccinic acid

Chemical Properties

Molecular Weight	182.22
Formula	C₄H₆O₄S₂
Cas No.	304-55-2
Smiles	[C@H]([C@H](C(O)=O)S)(C(O)=O)S
Relative Density.	1.617 g/cm3

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (274.39 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (10.98 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	5.4879 mL	27.4394 mL	54.8787 mL	274.3936 mL
5 mM	1.0976 mL	5.4879 mL	10.9757 mL	54.8787 mL
10 mM	0.5488 mL	2.7439 mL	5.4879 mL	27.4394 mL
20 mM	0.2744 mL	1.3720 mL	2.7439 mL	13.7197 mL
50 mM	0.1098 mL	0.5488 mL	1.0976 mL	5.4879 mL
100 mM	0.0549 mL	0.2744 mL	0.5488 mL	2.7439 mL

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc