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Anti-AASS Polyclonal Antibody
(Synonyms: Saccharopine dehydrogenase, Lysine ketoglutarate reductase, LORSDH, LKRSDH, LKR/SDH, alpha aminoadipic semialdehyde synthase mitochondrial, AASS_HUMAN) Copy Product Info
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Synonyms: Saccharopine dehydrogenase, Lysine ketoglutarate reductase, LORSDH, LKRSDH, LKR/SDH, alpha aminoadipic semialdehyde synthase mitochondrial, AASS_HUMAN
Catalog No. TMAB-02131 Copy Product Info
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Anti-AASS Polyclonal Antibody is a Rabbit antibody targeting AASS. Anti-AASS Polyclonal Antibody can be used in WB.
Anti-AASS Polyclonal Antibody
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 50 µL | $223 | 7-10 days | 7-10 days | |
| 100 µL | $374 | 7-10 days | 7-10 days | |
| 200 µL | $527 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
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| Description | Anti-AASS Polyclonal Antibody is a Rabbit antibody targeting AASS. Anti-AASS Polyclonal Antibody can be used in WB. |
| Synonyms | Saccharopine dehydrogenase, Lysine ketoglutarate reductase, LORSDH, LKRSDH, LKR/SDH, alpha aminoadipic semialdehyde synthase mitochondrial, AASS_HUMAN |
| Ig Type | IgG |
| Reactivity | Mouse (predicted:Human,Rat,Dog,Pig,Cow,Horse,Rabbit,Sheep) |
| Verified Activity | Sample: Liver (Mouse) Lysate at 40 μg Kidney (Mouse) Lysate at 40 μg Primary: Anti-AASS (TMAB-02131) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 99 kD Observed band size: 95 kD |
| Application | |
| Recommended Dose | WB: 1:500-2000 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Mitochondrial |
| Tissue Specificity | Expressed in all 16 tissues examined with highest expression in the liver. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | Alpha-aminoadipic semialdehyde synthase (AASS), also designated lysine ketoglutarate reductase (LKR) or saccharopine dehydrogenase (SDH), is a 926 amino acid protein that exists as a homodimer in the mitochondria. AASS acts as a bifunctional enzyme containing the lysine alpha-ketoglutarate reductase (LKR) and saccharopine dehydrogenase activities that catalyzes the first two steps in lysine degradation. It is widely expressed with highest expression in liver and transcription of the AASS gene is induced upon starvation. Mutations in the gene encoding AASS result in various forms familial hyperlysinemias (FH), autosomal recessive disorders characterized by hyperlysinemia, lysinuria, and variable saccharopinuria. However, no adverse mental or physical effects have been found in patients with hyperlysinemia. |
| Immunogen | KLH conjugated synthetic peptide: human LKRSDH |
| Antigen Species | Human |
| Gene Name | AASS |
| Gene ID | |
| Protein Name | alpha-aminoadipic semialdehyde synthase, mitochondrial |
| Uniprot ID | |
| Function | Bifunctional enzyme that catalyzes the first two steps in lysine degradation. The N-terminal and the C-terminal contain lysine-ketoglutarate reductase and saccharopine dehydrogenase activity, respectively. |
| Molecular Weight | Theoretical: 99 kDa. Actual: 95 kDa. |
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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