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Anti-AASS Polyclonal Antibody
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Catalog No. TMAB-02131
Alias Saccharopine dehydrogenase, Lysine ketoglutarate reductase, LORSDH, LKRSDH, LKR/SDH, alpha aminoadipic semialdehyde synthase mitochondrial, AASS_HUMAN
Anti-AASS Polyclonal Antibody is a Rabbit antibody targeting AASS. Anti-AASS Polyclonal Antibody can be used in WB.
Anti-AASS Polyclonal Antibody
Anti-AASS Polyclonal Antibody
Copy Product Info😃Good
Catalog No. TMAB-02131Alias Saccharopine dehydrogenase, Lysine ketoglutarate reductase, LORSDH, LKRSDH, LKR/SDH, alpha aminoadipic semialdehyde synthase mitochondrial, AASS_HUMAN
Anti-AASS Polyclonal Antibody is a Rabbit antibody targeting AASS. Anti-AASS Polyclonal Antibody can be used in WB.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $223 | 7-10 days | 7-10 days | |
| 100 μL | $374 | 7-10 days | 7-10 days | |
| 200 μL | $527 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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| Description | Anti-AASS Polyclonal Antibody is a Rabbit antibody targeting AASS. Anti-AASS Polyclonal Antibody can be used in WB. |
| Synonyms | Saccharopine dehydrogenase, Lysine ketoglutarate reductase, LORSDH, LKRSDH, LKR/SDH, alpha aminoadipic semialdehyde synthase mitochondrial, AASS_HUMAN |
| Ig Type | IgG |
| Reactivity | Mouse (predicted:Human,Rat,Dog,Pig,Cow,Horse,Rabbit,Sheep) |
| Verified Activity | Sample: Liver (Mouse) Lysate at 40 μg Kidney (Mouse) Lysate at 40 μg Primary: Anti-AASS (TMAB-02131) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 99 kD Observed band size: 95 kD |
| Application | |
| Recommended Dose | WB: 1:500-2000 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Mitochondrial |
| Tissue Specificity | Expressed in all 16 tissues examined with highest expression in the liver. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | Alpha-aminoadipic semialdehyde synthase (AASS), also designated lysine ketoglutarate reductase (LKR) or saccharopine dehydrogenase (SDH), is a 926 amino acid protein that exists as a homodimer in the mitochondria. AASS acts as a bifunctional enzyme containing the lysine alpha-ketoglutarate reductase (LKR) and saccharopine dehydrogenase activities that catalyzes the first two steps in lysine degradation. It is widely expressed with highest expression in liver and transcription of the AASS gene is induced upon starvation. Mutations in the gene encoding AASS result in various forms familial hyperlysinemias (FH), autosomal recessive disorders characterized by hyperlysinemia, lysinuria, and variable saccharopinuria. However, no adverse mental or physical effects have been found in patients with hyperlysinemia. |
| Immunogen | KLH conjugated synthetic peptide: human LKRSDH |
| Antigen Species | Human |
| Gene Name | AASS |
| Gene ID | |
| Protein Name | alpha-aminoadipic semialdehyde synthase, mitochondrial |
| Uniprot ID | |
| Function | Bifunctional enzyme that catalyzes the first two steps in lysine degradation. The N-terminal and the C-terminal contain lysine-ketoglutarate reductase and saccharopine dehydrogenase activity, respectively. |
| Molecular Weight | Theoretical: 99 kDa. |
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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