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Anti-MERS-D12 mAb
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Catalog No. T76669
Alias MERS-D12, MERS Antibody-D12
Anti-MERS-D12 mAb is a fully human monoclonal neutralizing antibody isolated from a recovered patient. It binds specifically to the receptor-binding domain (RBD) of the MERS-CoV spike glycoprotein with extremely high affinity, effectively blocking the interaction between the virus and the host receptor dipeptidyl peptidase 4 (DPP4). This action exerts potent neutralizing activity by preventing viral attachment and entry into host cells.
Anti-MERS-D12 mAb
Anti-MERS-D12 mAb
Copy Product Info😃Good
Catalog No. T76669Alias MERS-D12, MERS Antibody-D12
Anti-MERS-D12 mAb is a fully human monoclonal neutralizing antibody isolated from a recovered patient. It binds specifically to the receptor-binding domain (RBD) of the MERS-CoV spike glycoprotein with extremely high affinity, effectively blocking the interaction between the virus and the host receptor dipeptidyl peptidase 4 (DPP4). This action exerts potent neutralizing activity by preventing viral attachment and entry into host cells.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 5 mg | Inquiry | Inquiry | Inquiry |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Chemical Properties
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Storage & Solubility Information
| Description | Anti-MERS-D12 mAb is a fully human monoclonal neutralizing antibody isolated from a recovered patient. It binds specifically to the receptor-binding domain (RBD) of the MERS-CoV spike glycoprotein with extremely high affinity, effectively blocking the interaction between the virus and the host receptor dipeptidyl peptidase 4 (DPP4). This action exerts potent neutralizing activity by preventing viral attachment and entry into host cells. |
| Targets&IC50 | MERS-CoV:< 10 ng/mL |
| In vitro | In vitro neutralization assays, Anti-MERS-D12 mAb demonstrated ultrapotent neutralizing activity against MERS-CoV, with IC50 values often in the low ng/mL range (e.g., <10 ng/mL), by cross-linking and blocking the interaction of the viral RBD with the cellular DPP4 receptor [1]. |
| In vivo | In prophylactic and therapeutic pharmacological studies using hDPP4-transgenic mouse models infected with MERS-CoV, single-dose administration of Anti-MERS-D12 mAb significantly reduced pulmonary viral titers to undetectable levels and provided 100% protection against lethal challenge, preventing virus-induced weight loss and lung pathology [1]. |
| Synonyms | MERS-D12, MERS Antibody-D12 |
| Reactivity | Human |
| Application | FACS Functional assay |
| Antibody Type | Monoclonal |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Uniprot ID | |
| Target | MERS-D12 |
| Isotype | IgG |
| Storage | store at low temperature | -20°C for 2 years, 4°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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