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Scopolamine hydrobromide

Name: Scopolamine hydrobromide
Brand: TargetMol
SKU: T2725
Rating: 4.5 (1 reviews)

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Catalog No. T2725Cas No. 114-49-8

Alias Scopolamine HBr, Scopine hydrobromide, Hyoscine hydrobromide, (-)-Scopolamine hydrobromide

Scopolamine hydrobromide is a tropane alkaloid derived from the Solanaceae family. It is a high-affinity (nanomolar level) muscarinic receptor antagonist and can also reversibly inhibit 5-HT₃ receptor responses (IC₅₀ = 2.09 μM). It is commonly used to induce animal models of Alzheimer's disease or memory impairment.

Scopolamine hydrobromide

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Purity: 99.83%

Catalog No. T2725Alias Scopolamine HBr, Scopine hydrobromide, Hyoscine hydrobromide, (-)-Scopolamine hydrobromideCas No. 114-49-8

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Purity:99.83%

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Product Introduction

Bioactivity

Description	Scopolamine hydrobromide is a tropane alkaloid derived from the Solanaceae family. It is a high-affinity (nanomolar level) muscarinic receptor antagonist and can also reversibly inhibit 5-HT₃ receptor responses (IC₅₀ = 2.09 μM). It is commonly used to induce animal models of Alzheimer's disease or memory impairment.
Targets&IC50	5-HT3 receptor:2.09 μM, mAChR:55.3 nM
Synonyms	Scopolamine HBr, Scopine hydrobromide, Hyoscine hydrobromide, (-)-Scopolamine hydrobromide

Chemical Properties

Molecular Weight	384.26
Formula	C₁₇H₂₂BrNO₄
Cas No.	114-49-8
Smiles	[C@H]12C[C@@H](C[C@H]([C@@H]3[C@H]1O3)N2C)OC(=O)[C@H](CO)c1ccccc1.Br
Relative Density.	no data available
Color	White
Appearance	solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 197.8 mM, Sonication is recommended.

DMSO: 197.8 mM, Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 1 mg/mL (2.6 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6024 mL	13.0120 mL	26.0240 mL	130.1202 mL
5 mM	0.5205 mL	2.6024 mL	5.2048 mL	26.0240 mL
10 mM	0.2602 mL	1.3012 mL	2.6024 mL	13.0120 mL
20 mM	0.1301 mL	0.6506 mL	1.3012 mL	6.5060 mL
50 mM	0.0520 mL	0.2602 mL	0.5205 mL	2.6024 mL
100 mM	0.0260 mL	0.1301 mL	0.2602 mL	1.3012 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc