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Scopolamine hydrobromide

Name: Scopolamine hydrobromide
Brand: TargetMol
SKU: T2725
Rating: 4.5 (1 reviews)

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Catalog No. T2725Cas No. 114-49-8

Alias Scopolamine HBr, Scopine hydrobromide, Hyoscine hydrobromide, (-)-Scopolamine hydrobromide

Scopolamine hydrobromide is a tropane alkaloid derived from the Solanaceae family. It is a high-affinity (nanomolar level) muscarinic receptor antagonist and can also reversibly inhibit 5-HT₃ receptor responses (IC₅₀ = 2.09 μM). It is commonly used to induce animal models of Alzheimer's disease or memory impairment.

Scopolamine hydrobromide

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Purity: 99.83%

Catalog No. T2725Alias Scopolamine HBr, Scopine hydrobromide, Hyoscine hydrobromide, (-)-Scopolamine hydrobromideCas No. 114-49-8

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Purity:99.83%

Appearance:solid

Color:White

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Product Introduction

Bioactivity

Description	Scopolamine hydrobromide is a tropane alkaloid derived from the Solanaceae family. It is a high-affinity (nanomolar level) muscarinic receptor antagonist and can also reversibly inhibit 5-HT₃ receptor responses (IC₅₀ = 2.09 μM). It is commonly used to induce animal models of Alzheimer's disease or memory impairment.
Targets&IC50	mAChR:55.3 nM, 5-HT3 receptor:2.09 μM
Synonyms	Scopolamine HBr, Scopine hydrobromide, Hyoscine hydrobromide, (-)-Scopolamine hydrobromide

Chemical Properties

Molecular Weight	384.26
Formula	C₁₇H₂₂BrNO₄
Cas No.	114-49-8
Smiles	[C@H]12C[C@@H](C[C@H]([C@@H]3[C@H]1O3)N2C)OC(=O)[C@H](CO)c1ccccc1.Br
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 197.8 mM, Sonication is recommended.

DMSO: 197.8 mM, Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 1 mg/mL (2.6 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6024 mL	13.0120 mL	26.0240 mL	130.1202 mL
5 mM	0.5205 mL	2.6024 mL	5.2048 mL	26.0240 mL
10 mM	0.2602 mL	1.3012 mL	2.6024 mL	13.0120 mL
20 mM	0.1301 mL	0.6506 mL	1.3012 mL	6.5060 mL
50 mM	0.0520 mL	0.2602 mL	0.5205 mL	2.6024 mL
100 mM	0.0260 mL	0.1301 mL	0.2602 mL	1.3012 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc