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Sunvozertinib

Name: Sunvozertinib
Brand: TargetMol
SKU: T64124
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T64124Cas No. 2370013-12-8

Alias DZD-9008, DZD9008, DZD 9008

Sunvozertinib (DZD9008) is a potent ErbBs and BTK inhibitor, with inhibitory effects on EGFR, Her2, and mutant epidermal growth factor. Sunvozertinib (DZD9008) showed inhibitory effects on EGFR exon 20 NPH insertion, EGFR exon 20 ASV insertion, EGFR L858R and T790M mutations, as well as Her2 exon 20 YVMA and EGFR WT A431 with IC50 of 20.4, 20.4, 1.1, 7.5, and 80.4 nM.

Sunvozertinib

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Purity: 99.63%

Catalog No. T64124Alias DZD-9008, DZD9008, DZD 9008Cas No. 2370013-12-8

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$30	In Stock	In Stock
5 mg	$58	In Stock	In Stock
10 mg	$82	In Stock	In Stock
25 mg	$133	In Stock	In Stock
50 mg	$223	In Stock	In Stock
100 mg	$392	In Stock	In Stock
500 mg	$1,460	-	In Stock
1 mL x 10 mM (in DMSO)	$162	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.63%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Sunvozertinib (DZD9008) is a potent ErbBs and BTK inhibitor, with inhibitory effects on EGFR, Her2, and mutant epidermal growth factor. Sunvozertinib (DZD9008) showed inhibitory effects on EGFR exon 20 NPH insertion, EGFR exon 20 ASV insertion, EGFR L858R and T790M mutations, as well as Her2 exon 20 YVMA and EGFR WT A431 with IC50 of 20.4, 20.4, 1.1, 7.5, and 80.4 nM.
Targets&IC50	EGFR (L858R/T790M):1.1 nM, HER2 exon20 YVMA:7.5 nM, EGFR (exon 20 insertion):20.4 nM
In vitro	METHODS: To test the cellular activity of Sunvozertinib (DZD9008) , 14 different EGFRexon20ins were engineered into the Ba/F3 cell line. RESULTS In these cell lines, Sunvozertinib (DZD9008) showed potent pEGFR downregulation activity with IC50 ranging from 6 to 40 nM; in other cell lines expressing EGFR sensitive mutations, T790M resistance mutations, and rare mutations, Sunvozertinib (DZD9008) downregulated pEGFR more effectively with IC50 ranging from 1.1 to 12 nM; in the A431 cell line overexpressing wild-type EGFR, Sunvozertinib (DZD9008) was less potent in downregulating pEGFR with an IC50 of 58 nM. [1]
In vivo	METHODS: Blood samples from the LU3075 PDX mouse model were collected at 0.5, 1, 2, 4, 8, and 24 hours after administration of sunvozertinib (DZD9008) (12.5, 25, and 50 mg/kg, orally, twice daily) on day 28 for LC/MS-MS analysis. RESULTS Oral sunvozertinib (DZD9008) showed profound anti-tumor efficacy in a dose-dependent manner. [2]
Synonyms	DZD-9008, DZD9008, DZD 9008

Chemical Properties

Molecular Weight	584.08
Formula	C₂₉H₃₅ClFN₇O₃
Cas No.	2370013-12-8
Smiles	COc1cc(N2CC[C@H](C2)N(C)C)c(NC(=O)C=C)cc1Nc1nccc(Nc2cc(Cl)c(F)cc2C(C)(C)O)n1

Storage & Solubility Information

Storage

keep away from direct sunlight,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 247.5 mg/mL (423.74 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (8.56 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7121 mL	8.5605 mL	17.1209 mL	85.6047 mL
5 mM	0.3424 mL	1.7121 mL	3.4242 mL	17.1209 mL
10 mM	0.1712 mL	0.8560 mL	1.7121 mL	8.5605 mL
20 mM	0.0856 mL	0.4280 mL	0.8560 mL	4.2802 mL
50 mM	0.0342 mL	0.1712 mL	0.3424 mL	1.7121 mL
100 mM	0.0171 mL	0.0856 mL	0.1712 mL	0.8560 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc