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Sunvozertinib

Catalog No. T64124 CAS 2370013-12-8

Synonyms: DZD9008, DZD 9008, DZD-9008

Sunvozertinib (DZD9008) is a potent ErbBs and BTK inhibitor and has inhibitory effects on EGFR, Her2 and mutant epidermal growth factor. Sunvozertinib showed inhibition of EGFR exon 20 NPH insertion, EGFR exon 20 ASV insertion, EGFR L858R and T790M mutation, and Her2 exon 20 YVMA and EGFR WT A431. IC50 were 20.4, 20.4, 1.1, 7.5 and 80.4 nM, respectively.

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Sunvozertinib, CAS 2370013-12-8

Pack Size	Availability	Price/USD
1 mg	In stock	$ 60.00
5 mg	In stock	$ 147.00
10 mg	In stock	$ 239.00
25 mg	In stock	$ 478.00
50 mg	In stock	$ 688.00
100 mg	In stock	$ 980.00
500 mg	In stock	$ 1,960.00
1 mL * 10 mM (in DMSO)	In stock	$ 162.00

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Purity: 98.11%

Biological Description

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Description	Sunvozertinib (DZD9008) is a potent ErbBs and BTK inhibitor and has inhibitory effects on EGFR, Her2 and mutant epidermal growth factor. Sunvozertinib showed inhibition of EGFR exon 20 NPH insertion, EGFR exon 20 ASV insertion, EGFR L858R and T790M mutation, and Her2 exon 20 YVMA and EGFR WT A431. IC50 were 20.4, 20.4, 1.1, 7.5 and 80.4 nM, respectively.
Targets&IC50	EGFR (L858R/T790M):1.1 nM, HER2 exon20 YVMA:7.5 nM, EGFR (exon 20 insertion):20.4 nM
In vitro	Sunvozertinib inhibits p-BTK with an IC50 of 1.6 nM.[1] The GI50 of Sunvozertinib against EGFR exon NPH insertion, EGFR exon 20 ASV insertion, EGFR L858R and T790M mutations, Her2 Exon20 YVMA, and EGFR WT was 60.4, 83.2, 3.3, 101.3, and 47.1 nM A431, respectively. The GI50 of Sunvozertinib for BTK WT OCI-LY-10, BTK WT TMD-8, BTK WT Ri-1, and non-BCR activated DB was 3.2, 5.8, 51.3 and 1983.5 nM, respectively.[1]

Synonyms	DZD9008, DZD 9008, DZD-9008
Molecular Weight	584.08
Formula	C29H35ClFN7O3
CAS No.	2370013-12-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 55 mg/mL (94.16 mM), Sonication and heating are recommended.

References and Literature

1. Zhengtao LI, et al. Erbb/btk inhibitors. WO2019149164A1.

Related compound libraries

This product is contained In the following compound libraries：

Tyrosine Kinase Inhibitor Library Anti-Cancer Drug Library Drug Repurposing Compound Library Membrane Protein-targeted Compound Library Anti-Cancer Active Compound Library FDA-Approved Kinase Inhibitor Library Anti-Cancer Approved Drug Library Kinase Inhibitor Library Inhibitor Library Anti-Cancer Clinical Compound Library

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PAT-505 EGFR-IN-99 Becotatug AZD8931 diFuMaric acid EGFR-IN-82 Simotinib EGFR-IN-2 EGFR-IN-1

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Keywords

Sunvozertinib 2370013-12-8 Angiogenesis JAK/STAT signaling Tyrosine Kinase/Adaptors EGFR BTK DZD9008 DZD 9008 DZD-9008 inhibitor inhibit

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