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PEG300

Name: PEG300
Brand: TargetMol
SKU: T7022
Price: 48 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T7022Cas No. 25322-68-3

Alias Polyethylene glycol 300

PEG300 (Polyethylene glycol 300) is a polymer formed from repeating units of ethylene glycol that is water soluble, low immunogenicity, and biocompatible. PEG300 is a neutral polymer with a molecular weight of 300.

PEG300

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Catalog No. T7022Alias Polyethylene glycol 300Cas No. 25322-68-3

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
100 mL	$48	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	PEG300 (Polyethylene glycol 300) is a polymer formed from repeating units of ethylene glycol that is water soluble, low immunogenicity, and biocompatible. PEG300 is a neutral polymer with a molecular weight of 300.
In vitro	METHODS: Human colorectal adenocarcinoma cells Caco-2 were treated with PEG300 (30 w/v% in 100 μL) for 30 min, and cell growth inhibition was detected by MTT. RESULTS: PEG300 treatment severely reduced cell viability, and the cell survival rate was only 20%. [1]
In vivo	METHODS: To study the effect of Dasatinib on diabetic cardiomyopathy, Dasatinib (5 mg/kg in 10% DMSO + 90% PEG-300) was administered by gavage to BKS.Cg-+Leprdb/+Leprdb/OlaHsd (db/db) mice once a week for four weeks. RESULTS: Dasatinib counteracted obesity in the heart and bone marrow as well as cardiac fibrosis. [2] METHODS: To test the in vivo effects of treatment with ALW-II-41-27 (an EPHA2 inhibitor) and/or cetuximab, cetuximab (25 mg/kg in 10% 1-methyl-2-pyrrolidinone + 90% PEG 300 twice weekly) and ALW-II-41-27 (30 mg/kg/day) were injected intraperitoneally into balb/c athymic (nu+/nu+) mice bearing human colorectal adenocarcinoma tumor HCT15 for six weeks. RESULTS: The combination of ALW-II-41-27 and cetuximab significantly inhibited tumor growth. [3]
Synonyms	Polyethylene glycol 300

Chemical Properties

Molecular Weight	722.863
Formula	C₃₂H₆₆O₁₇
Cas No.	25322-68-3
Smiles	OCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO
Relative Density.	1.1 g/cm3. Temperature:30 °C.

Storage & Solubility Information

Storage

store at -80°C | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100.00 mg/mL (138.34 mM), Sonication is recommended.

H2O: 50.00 mg/mL (69.17 mM), Sonication is recommended.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	1.3834 mL	6.9169 mL	13.8339 mL	69.1694 mL
5 mM	0.2767 mL	1.3834 mL	2.7668 mL	13.8339 mL
10 mM	0.1383 mL	0.6917 mL	1.3834 mL	6.9169 mL
20 mM	0.0692 mL	0.3458 mL	0.6917 mL	3.4585 mL
50 mM	0.0277 mL	0.1383 mL	0.2767 mL	1.3834 mL

DMSO

	1mg	5mg	10mg	50mg
100 mM	0.0138 mL	0.0692 mL	0.1383 mL	0.6917 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

polymerPolyethylene glycol-300Polyethylene glycol300PEG-300PEG300PEG 300markerInhibitorinhibitimmunogenicgastrointestinalbiocompatible