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Lactic acid sodium (60% w/w in water)
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Catalog No. T212648Cas No. 72-17-3
Alias E-270 sodium (60% w/w in water), DL-Lactic acid sodium (60% w/w in water)
Lactic acid (DL-Lactic acid) sodium (60% w/w in water) is an activator of hydroxycarboxylic acid receptor 1 (HCAR1) and an epigenetic regulator that induces lysine residue lactylation. As the end product of glycolysis, it bridges the gap between glycolysis and oxidative phosphorylation. This compound is a tumor metabolite, offering immunoprotective effects of lactate in antitumor immunity. Additionally, it possesses antimicrobial properties and can be used as a food preservative.
Lactic acid sodium (60% w/w in water)
Copy Product Info😃Good
Catalog No. T212648Alias E-270 sodium (60% w/w in water), DL-Lactic acid sodium (60% w/w in water)Cas No. 72-17-3
Lactic acid (DL-Lactic acid) sodium (60% w/w in water) is an activator of hydroxycarboxylic acid receptor 1 (HCAR1) and an epigenetic regulator that induces lysine residue lactylation. As the end product of glycolysis, it bridges the gap between glycolysis and oxidative phosphorylation. This compound is a tumor metabolite, offering immunoprotective effects of lactate in antitumor immunity. Additionally, it possesses antimicrobial properties and can be used as a food preservative.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | 10-14 weeks | 10-14 weeks | |
| 50 mg | Inquiry | 10-14 weeks | 10-14 weeks |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
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Chemical Properties
Storage & Solubility Information
| Description | Lactic acid (DL-Lactic acid) sodium (60% w/w in water) is an activator of hydroxycarboxylic acid receptor 1 (HCAR1) and an epigenetic regulator that induces lysine residue lactylation. As the end product of glycolysis, it bridges the gap between glycolysis and oxidative phosphorylation. This compound is a tumor metabolite, offering immunoprotective effects of lactate in antitumor immunity. Additionally, it possesses antimicrobial properties and can be used as a food preservative. |
| In vitro | Lactic acid (20 mM; 24, 48 hours) combined with sodium (60% w/w in water) significantly reduces cell proliferation and migration, altering cellular metabolism towards oxidative phosphorylation. Additionally, lactic acid (20 mM; 24 hours) with sodium (60% w/w in water) increases the protein and mRNA expression levels of MCT1 and HCAR1. |
| In vivo | Lactic acid (1.6 g/kg; pH 7.4; subcutaneous injection; once daily; from day 8 to 30) with sodium (60% w/w in water) exhibits CD8+ T cell-dependent tumor growth inhibition in the MC38 colon cancer model. Note: Adjust the working solution's pH to approximately 7.4 before administration in animals. |
| Synonyms | E-270 sodium (60% w/w in water), DL-Lactic acid sodium (60% w/w in water) |
| Molecular Weight | 112.06 |
| Formula | C3H5NaO3 |
| Cas No. | 72-17-3 |
| Smiles | O=C(C(C)O)[O-].[Na+] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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