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Lactic acid sodium (60% w/w in water)

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Catalog No. T212648Cas No. 72-17-3

Lactic acid (DL-Lactic acid) sodium (60% w/w in water) is an activator of hydroxycarboxylic acid receptor 1 (HCAR1) and an epigenetic regulator that induces lysine residue lactylation. As the end product of glycolysis, it bridges the gap between glycolysis and oxidative phosphorylation. This compound is a tumor metabolite, offering immunoprotective effects of lactate in antitumor immunity. Additionally, it possesses antimicrobial properties and can be used as a food preservative.

Lactic acid sodium (60% w/w in water)

Lactic acid sodium (60% w/w in water)

😃Good
Catalog No. T212648Cas No. 72-17-3
Lactic acid (DL-Lactic acid) sodium (60% w/w in water) is an activator of hydroxycarboxylic acid receptor 1 (HCAR1) and an epigenetic regulator that induces lysine residue lactylation. As the end product of glycolysis, it bridges the gap between glycolysis and oxidative phosphorylation. This compound is a tumor metabolite, offering immunoprotective effects of lactate in antitumor immunity. Additionally, it possesses antimicrobial properties and can be used as a food preservative.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
10 mgInquiry10-14 weeks10-14 weeks
50 mgInquiry10-14 weeks10-14 weeks
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Bioactivity
Description
Lactic acid (DL-Lactic acid) sodium (60% w/w in water) is an activator of hydroxycarboxylic acid receptor 1 (HCAR1) and an epigenetic regulator that induces lysine residue lactylation. As the end product of glycolysis, it bridges the gap between glycolysis and oxidative phosphorylation. This compound is a tumor metabolite, offering immunoprotective effects of lactate in antitumor immunity. Additionally, it possesses antimicrobial properties and can be used as a food preservative.
In vitro
Lactic acid (20 mM; 24, 48 hours) combined with sodium (60% w/w in water) significantly reduces cell proliferation and migration, altering cellular metabolism towards oxidative phosphorylation. Additionally, lactic acid (20 mM; 24 hours) with sodium (60% w/w in water) increases the protein and mRNA expression levels of MCT1 and HCAR1.
In vivo
Lactic acid (1.6 g/kg; pH 7.4; subcutaneous injection; once daily; from day 8 to 30) with sodium (60% w/w in water) exhibits CD8+ T cell-dependent tumor growth inhibition in the MC38 colon cancer model. Note: Adjust the working solution's pH to approximately 7.4 before administration in animals.
Chemical Properties
Molecular Weight112.06
FormulaC3H5NaO3
Cas No.72-17-3
SmilesO=C(C(C)O)[O-].[Na+]
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Stock solution preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (stock solution concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
The above example illustrates how to use "In Vivo Formulation Calculator" and does not represent a recommended formulation for any specific compound. Please select an appropriate dissolution method based on your experimental animals and route of administration.
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1 Enter information below:
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2 Enter the in vivo formulation:
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