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Lactic acid (DL-Lactic acid) sodium (60% w/w in water) is an activator of hydroxycarboxylic acid receptor 1 (HCAR1) and an epigenetic regulator that induces lysine residue lactylation. As the end product of glycolysis, it bridges the gap between glycolysis and oxidative phosphorylation. This compound is a tumor metabolite, offering immunoprotective effects of lactate in antitumor immunity. Additionally, it possesses antimicrobial properties and can be used as a food preservative.

| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | 10-14 weeks | 10-14 weeks | |
| 50 mg | Inquiry | 10-14 weeks | 10-14 weeks |
| Description | Lactic acid (DL-Lactic acid) sodium (60% w/w in water) is an activator of hydroxycarboxylic acid receptor 1 (HCAR1) and an epigenetic regulator that induces lysine residue lactylation. As the end product of glycolysis, it bridges the gap between glycolysis and oxidative phosphorylation. This compound is a tumor metabolite, offering immunoprotective effects of lactate in antitumor immunity. Additionally, it possesses antimicrobial properties and can be used as a food preservative. |
| In vitro | Lactic acid (20 mM; 24, 48 hours) combined with sodium (60% w/w in water) significantly reduces cell proliferation and migration, altering cellular metabolism towards oxidative phosphorylation. Additionally, lactic acid (20 mM; 24 hours) with sodium (60% w/w in water) increases the protein and mRNA expression levels of MCT1 and HCAR1. |
| In vivo | Lactic acid (1.6 g/kg; pH 7.4; subcutaneous injection; once daily; from day 8 to 30) with sodium (60% w/w in water) exhibits CD8+ T cell-dependent tumor growth inhibition in the MC38 colon cancer model. Note: Adjust the working solution's pH to approximately 7.4 before administration in animals. |
| Molecular Weight | 112.06 |
| Formula | C3H5NaO3 |
| Cas No. | 72-17-3 |
| Smiles | O=C(C(C)O)[O-].[Na+] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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