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Dimethoxycurcumin
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Catalog No. T19853Cas No. 160096-59-3
Alias Veratrylcurcuminoid
Dimethoxycurcumin (Veratrylcurcuminoid) is an analog of curcumin with more metabolical stability. Dimethoxycurcumin induces epigenetic changes in leukemia cells and the expression of promoter methylated genes.
Dimethoxycurcumin
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Purity: 99.87%
Catalog No. T19853Alias VeratrylcurcuminoidCas No. 160096-59-3
Dimethoxycurcumin (Veratrylcurcuminoid) is an analog of curcumin with more metabolical stability. Dimethoxycurcumin induces epigenetic changes in leukemia cells and the expression of promoter methylated genes.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 5 mg | $46 | In Stock | In Stock | |
| 10 mg | $74 | In Stock | In Stock | |
| 25 mg | $143 | In Stock | In Stock | |
| 50 mg | $251 | In Stock | In Stock | |
| 100 mg | $367 | In Stock | In Stock | |
| 200 mg | $523 | In Stock | In Stock | |
| 1 mL x 10 mM (in DMSO) | $51 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.87%
Appearance:Solid
Color:Yellow
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Product Introduction
Dimethoxycurcumin AI Summary
Dimethoxycurcumin exhibits a range of bioactivities, including antimalarial, antiproliferative, antitrypanosomal, antileishmanial, antimycobacterial, and cellular defense activation properties. It shows antimalarial activity against both chloroquine-sensitive and chloroquine-resistant strains of Plasmodium falciparum with moderate potency, as indicated by its IC50 values. The compound also displays antiproliferative activity against human SKBR3 and MCF7 cancer cell lines with IC50 values of 955.0 nM and 1070.0 nM, respectively.
In terms of antitrypanosomal activity, Dimethoxycurcumin is effective against various strains of Trypanosoma brucei brucei, with EC50 values ranging from 450.0 nM to over 4000.0 nM, depending on the strain's resistance. It also has antileishmanial activity against Leishmania major Friedlin promastigotes and Leishmania mexicana amastigotes with EC50 values of 2800.0 nM and 10000.0 nM, respectively.
For antimycobacterial activity, it inhibits Mycobacterium tuberculosis H37Ra with a MIC of 100.0 ug/mL. Furthermore, Dimethoxycurcumin activates Nrf2 in human HepG2 cells significantly, showing a fold change of 35.7 and an EC50 value of 16600.0 nM for Nrf2 activation.
Additionally, the compound displays cytotoxicity against human HEK293 cells with an EC50 value of 200000.0 nM and a selectivity index of 70.0 for Leishmania species. These diverse bioactivities suggest its potential for various therapeutic applications, although further studies are needed to optimize its efficacy and safety..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Dimethoxycurcumin (Veratrylcurcuminoid) is an analog of curcumin with more metabolical stability. Dimethoxycurcumin induces epigenetic changes in leukemia cells and the expression of promoter methylated genes. |
| Synonyms | Veratrylcurcuminoid |
| Molecular Weight | 396.43 |
| Formula | C23H24O6 |
| Cas No. | 160096-59-3 |
| Smiles | O(C)C1=C(OC)C=CC(/C=C/C(CC(/C=C/C2=CC(OC)=C(OC)C=C2)=O)=O)=C1 |
| Relative Density. | 1.169g/cm3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 50 mg/mL (126.13 mM), Sonication is recommended.  Ethanol: ≤ 0.25 mg/mL (insoluble or slightly soluble) dimethyl formamide: 10 mg/mL (25.23 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
dimethyl formamide/DMSO
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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