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Sanguisorbigenin

Name: Sanguisorbigenin
Brand: TargetMol
SKU: TN4943
Price: 163 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. TN4943Cas No. 6812-98-2

Alias Ursa-12,19-dien-28-oic acid, Tomentosolic acid, 3β-Hydroxyurs-12,19-dien-28-oic acid, 19-Dehydroursolic acid

Sanguisorbigenin (Tomentosolic acid) is a natural antimicrobial agent that inhibits methicillin-resistant Staphylococcus aureus (MRSA).

Sanguisorbigenin

🥰Excellent

Purity: 99.56%

Catalog No. TN4943Alias Ursa-12,19-dien-28-oic acid, Tomentosolic acid, 3β-Hydroxyurs-12,19-dien-28-oic acid, 19-Dehydroursolic acidCas No. 6812-98-2

Sanguisorbigenin (Tomentosolic acid) is a natural antimicrobial agent that inhibits methicillin-resistant Staphylococcus aureus (MRSA).

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$163	In Stock	In Stock
5 mg	$398	In Stock	In Stock
10 mg	$596	In Stock	In Stock
25 mg	$882	In Stock	In Stock
50 mg	$1,190	In Stock	In Stock
100 mg	$1,600	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$458	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.56%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	Sanguisorbigenin (Tomentosolic acid) is a natural antimicrobial agent that inhibits methicillin-resistant Staphylococcus aureus (MRSA).
In vitro	Treatment of Sanguisorbigenin with sub-MIC concentrations (1.56-6.25 μg/mL) significantly inhibited the expression of blaR1, mecA, and blaZ in MRSA dose-dependently. The gene expression of mecA is remarkably reduced after the treatment of Sanguisorbigenin. The minimal inhibitory concentration values of Sanguisorbigenin against six strains of S. aureus are in the range of 12.5-50 μg/mL[1]. Sanguisorbigenin has a potent antibacterial effect and could effectively reverse the sense of antibiotics by inhibiting the mecA expression and decreasing PBP2a expression[1].
Synonyms	Ursa-12,19-dien-28-oic acid, Tomentosolic acid, 3β-Hydroxyurs-12,19-dien-28-oic acid, 19-Dehydroursolic acid

Chemical Properties

Molecular Weight	454.69
Formula	C₃₀H₄₆O₃
Cas No.	6812-98-2
Smiles	[H][C@@]12CC[C@]3(C)[C@]([H])(CC=C4[C@]5([H])C(C)=C(C)CC[C@@]5(CC[C@@]34C)C(O)=O)[C@@]1(C)CC[C@H](O)C2(C)C
Relative Density.	1.11 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (131.96 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 1.67 mg/mL (3.67 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1993 mL	10.9965 mL	21.9930 mL	109.9650 mL
5 mM	0.4399 mL	2.1993 mL	4.3986 mL	21.9930 mL
10 mM	0.2199 mL	1.0997 mL	2.1993 mL	10.9965 mL
20 mM	0.1100 mL	0.5498 mL	1.0997 mL	5.4983 mL
50 mM	0.0440 mL	0.2199 mL	0.4399 mL	2.1993 mL
100 mM	0.0220 mL	0.1100 mL	0.2199 mL	1.0997 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc