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Tylosin phosphate

Name: Tylosin phosphate
Brand: TargetMol
SKU: TP2300
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Tylosin phosphate is a broad-spectrum macrolide antibiotic produced by Streptomyces freii and intended exclusively for animal use. Tylosin phosphate inhibits bacterial protein synthesis by reversibly binding to the 50S ribosomal subunit; it exhibits high antibacterial activity, particularly against Gram-positive bacteria, mycoplasmas, and certain Gram-negative bacteria. Tylosin phosphate is a feed additive widely used to promote animal growth. It is also used in research on bacterial dysentery and respiratory diseases in poultry, swine, and cattle.

Cas No. 1405-53-4

Pack Size	Price	USA Stock	Global Stock	Quantity
1 g	$30	-	In Stock
1 mL x 10 mM (in DMSO)	$29	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Appearance:Solid

Color:White

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Product Introduction

Bioactivity

Description	Tylosin phosphate is a broad-spectrum macrolide antibiotic produced by Streptomyces freii and intended exclusively for animal use. Tylosin phosphate inhibits bacterial protein synthesis by reversibly binding to the 50S ribosomal subunit; it exhibits high antibacterial activity, particularly against Gram-positive bacteria, mycoplasmas, and certain Gram-negative bacteria. Tylosin phosphate is a feed additive widely used to promote animal growth. It is also used in research on bacterial dysentery and respiratory diseases in poultry, swine, and cattle.
In vitro	Tylosin phosphate also prevents growth of Gram-negative strains, with MICs of 64 μg/mL, 32 μg/mL, 512 μg/mL and 1 μg/mL for M. haemolytica 11935, P. multocida 4407, E. coli ATCC 25922 and E. coli AS19rlmAI, respectively.[2]
In vivo	Methods: Tylosin phosphate was administered subcutaneously to Balb/C mice at doses of 10 mg/kg, 100 mg/kg, and 500 mg/kg, followed by intraperitoneal injection of 250 μg of LPS. Mice were euthanized in batches at 0, 1, 2, 3, 6, 12, and 24 hours post-administration, and serum was collected via cardiac puncture. Results: Tylosin phosphate significantly reversed LPS-induced cytokine dysregulation. [1]

Chemical Properties

Molecular Weight	1014.1
Formula	C₄₆H₈₀NO₂₁P
Cas No.	1405-53-4
Smiles	O([C@H]1[C@H](N(C)C)[C@@H](O)[C@H](O[C@H]2[C@@H](CC=O)C[C@@H](C)C(=O)/C=C/C(/C)=C/[C@H](CO[C@H]3[C@H](OC)[C@H](OC)[C@H](O)[C@@H](C)O3)[C@@H](CC)OC(=O)C[C@@H](O)[C@@H]2C)O[C@@H]1C)[C@H]4C[C@@](C)(O)[C@@H](O)[C@H](C)O4.P(=O)(O)(O)O
Relative Density.	no data available

Storage & Solubility Information

Storage	Keep away from moisture Powder: -20°C for 3 years \| In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
Solubility Information	DMSO: Soluble

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Tylosin Phosphate

Related Tags: Tylosin phosphate chemical structure | Tylosin phosphate in vivo | Tylosin phosphate in vitro | Tylosin phosphate formula | Tylosin phosphate molecular weight