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Anti-EphA2 Antibody-PE (8N84)
🥰Excellent
Catalog No. TMAY-03368P
Anti-EphA2 Antibody-PE (8N84) is a PE-conjugated Rabbit antibody targeting EphA2. Anti-EphA2 Antibody-PE (8N84) can be used in FCM.
Anti-EphA2 Antibody-PE (8N84)
Anti-EphA2 Antibody-PE (8N84)
🥰Excellent
Catalog No. TMAY-03368P
Anti-EphA2 Antibody-PE (8N84) is a PE-conjugated Rabbit antibody targeting EphA2. Anti-EphA2 Antibody-PE (8N84) can be used in FCM.
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-EphA2 Antibody-PE (8N84) is a PE-conjugated Rabbit antibody targeting EphA2. Anti-EphA2 Antibody-PE (8N84) can be used in FCM. |
| Ig Type | Monoclonal Rabbit IgG |
| Clone | 8N84 |
| Reactivity | Mouse |
| Verified Activity | Flow cytometric analysis of Mouse EphA2 expression on MS-1 cells. Cells were stained with PE-conjugated anti-Mouse EphA2. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells. |
| Application | FCM |
| Recommended Dose | 5 μl/Test, 0.1 mg/ml |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Mouse EphA2 / Eph Receptor A2 (rM EphA2 / Eph Receptor A2; TMPY-01777; NP_034269.2; Met1-Asn535) and conjugated with PE under optimum conditions, the unreacted PE was removed. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | PBS solution containing 0.5% BSA and 0.09% sodium azide |
| Research Background | Eph receptor A2 (Ephrin type-A receptor 2 or EphA2) is a member of the ephrin receptor subfamily of the protein-tyrosine kinase family. The Eph receptors' corresponding family of ligands are the ephrins anchored to cell surfaces. The ephrins and Eph receptors are implicated as positional labels that may guide the development of neural topographic maps. They have also been found implicated in embryonic patterning, neuronal targeting, vascular development and adult neovascularization. The large family of ligands and receptors may make a major contribution to the accurate spatial patterning of connections and cell position in the nervous system. Furthermore, elevated expression of Eph receptors and ephrin ligands is associated with tumors and associated tumor vasculature, suggesting the Eph receptors and ephrin ligands also play critical roles in tumor angiogenesis and tumor growth. Unlike most Eph kinases, which are primarily expressed during development, EphA2 is primarily found in adult human epithelial cells. The cellular functions of EphA2 may be regulating cell growth, survival, migration, and angiogenesis.Unlike other receptor tyrosine kinases, ligand binding is not necessary for EphA2. Rather, the ligand appears to regulate EphA2 subcellular localization and its interactions with downstream adapter and signaling proteins. Eph receptor A2(EphA2) has been demonstrated to critically regulate tumor cell growth, migration and invasiveness. Eph receptor A2(EphA2) is frequently overexpressed and functionally altered in aggressive tumor cells, and that these changes promote metastatic character. |
| Conjucates | PE |
| Others Formats | Unconjugated/FITC |
| Antibody Types Available | 3 |
| Immunogen | Recombinant Mouse EphA2 / Eph Receptor A2 Protein (TMPY-01777) |
| Antigen Species | Mouse |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 12 months, do not freeze. Keep away from direct sunlight. Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal. |
| Transport | Shipping with blue ice. |
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