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GNE-6776

Name: GNE-6776
Brand: TargetMol
SKU: T4634
Price: 74 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T4634Cas No. 2009273-71-4

Alias GEN6776

GNE-6776 is a selective USP7 inhibitor.

GNE-6776

🥰Excellent

Purity: 98.2%

Catalog No. T4634Alias GEN6776Cas No. 2009273-71-4

GNE-6776 is a selective USP7 inhibitor.

Pack Size	Price	Availability
1 mg	$74	In Stock
5 mg	$178	In Stock
10 mg	$287	In Stock
25 mg	$552	In Stock
50 mg	$793	In Stock
100 mg	$1,080	In Stock
1 mL x 10 mM (in DMSO)	$197	In Stock

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Batch Information

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Purity:98.2%

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	GNE-6776 is a selective USP7 inhibitor.
In vitro	GNE-6776 non-covalently targets USP7 12?? distant from the catalytic cysteine. GNE-6776 attenuates ubiquitin binding and thus inhibits USP7 deubiquitinase activity. GNE-6776 interacts with acidic residues that mediate hydrogen-bond interactions with the ubiquitin Lys48 side chain. GNE-6776 targets cellular USP7, MDM2, and p53 signalling pathways.GNE-6776 selectively inhibits recombinant USP7 relative to 36 other deubiquitinases. GNE-6776 remains selective even at 100?μM, a more than sixfold higher concentration than used in cellular assays. GNE-6776 significantly inhibits USP7 while remaining selective against 44-47 other detected deubiquitinases.
In vivo	Although efficacious exposure is only transiently achieved, GNE-6776 causes modest, although significant, EOL-1 xenograft growth delay.
Synonyms	GEN6776

Chemical Properties

Molecular Weight	348.4
Formula	C₂₀H₂₀N₄O₂
Cas No.	2009273-71-4
Smiles	CCc1c(cnc(N)c1-c1ccc(O)cc1)-c1ccc(nc1)C(=O)NC
Relative Density.	1.242 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 310 mg/mL (889.78 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8703 mL	14.3513 mL	28.7026 mL	143.5132 mL
5 mM	0.5741 mL	2.8703 mL	5.7405 mL	28.7026 mL
10 mM	0.2870 mL	1.4351 mL	2.8703 mL	14.3513 mL
20 mM	0.1435 mL	0.7176 mL	1.4351 mL	7.1757 mL
50 mM	0.0574 mL	0.2870 mL	0.5741 mL	2.8703 mL
100 mM	0.0287 mL	0.1435 mL	0.2870 mL	1.4351 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc