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Anti-CASPR Polyclonal Antibody
😃Good
Catalog No. TMAB-03676
Anti-CASPR Polyclonal Antibody is a Rabbit antibody targeting CASPR. Anti-CASPR Polyclonal Antibody can be used in ICC/IF,FCM.
Anti-CASPR Polyclonal Antibody
Anti-CASPR Polyclonal Antibody
😃Good
Catalog No. TMAB-03676
Anti-CASPR Polyclonal Antibody is a Rabbit antibody targeting CASPR. Anti-CASPR Polyclonal Antibody can be used in ICC/IF,FCM.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $220 | 7-10 days | 7-10 days | |
| 100 μL | $374 | 7-10 days | 7-10 days | |
| 200 μL | $527 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-CASPR Polyclonal Antibody is a Rabbit antibody targeting CASPR. Anti-CASPR Polyclonal Antibody can be used in ICC/IF,FCM. |
| Ig Type | IgG |
| Reactivity | Human (predicted:Mouse,Rat,Dog,Pig,Cow,Horse) |
| Application | |
| Recommended Dose | ICC/IF: 1:100-500; FCM: 3μg/Test |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Membrane. |
| Tissue Specificity | Predominantly expressed in brain. Weak expression detected in ovary, pancreas, colon, lung, heart, intestine and testis. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | Neurexins comprise a family of neuronal cell surface proteins, which include neurexin I (NRXN1), neurexin II (NRXN2), neurexin III (NRXN3) and CASPR (neurexin IV). Neurexins I-III are expressed as å and ∫ isoforms. The å isoforms are made of three cassettes, which contain two LNS (laminin A, neurexins, sex hormone-binding)-domains separated by EGF domains, followed by a transmembrane region and a 55 amino acid cytoplasmic C-terminal. The å isoforms bind to neurexophilins at the second LNS site, and to the excitatory neurotoxin å-latrotoxin. The ∫ isoforms have only one LNS-domain, bind to neuroligins and play a role in the formation and remodeling of synapses. CASPR (for contactin-associated protein 1, also designated paranodin in mouse), contains an extracellular domain similar to the other three neurexins, and binds to the surface glycoprotein contactin. CASPR and the closely related CASPR2, a mammalian homolog of Drosophila neurexin IV (Nrx-IV), demarcate distinct subdomains in myelinated axons. Specifically, CASPR exists at the paranodal junctions, while CASPR2 co-localizes with Shaker-like K+ channels in the juxtaparanodal region. CASPR may play a role in the communication of glial cells and neurons during development. |
| Immunogen | KLH conjugated synthetic peptide: human CASPR/Neurexin4 |
| Antigen Species | Human |
| Gene Name | CNTNAP1 |
| Gene ID | |
| Protein Name | Contactin-associated protein 1 |
| Uniprot ID | |
| Function | Seems to play a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Seems to demarcate the paranodal region of the axo-glial junction. In association with contactin may have a role in the signaling between axons and myelinating glial cells. |
| Molecular Weight | Theoretical: 154 kDa. |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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