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cjoc42

🥰Excellent
Catalog No. T27029Cas No. 2171519-89-2
Alias cjoc-42, cjoc 42

Cjoc42 is an inhibitor of gankyrin, an ankyrin-repeat oncoprotein whose overexpression has been implicated in the development of many cancer types. cjoc42 prevents the decrease in p53 protein levels normally associated with high amounts of gankyrin, and it restores p53-dependent transcription and sensitivity to DNA damage

cjoc42

cjoc42

🥰Excellent
Purity: 99.56%
Catalog No. T27029Alias cjoc-42, cjoc 42Cas No. 2171519-89-2
Cjoc42 is an inhibitor of gankyrin, an ankyrin-repeat oncoprotein whose overexpression has been implicated in the development of many cancer types. cjoc42 prevents the decrease in p53 protein levels normally associated with high amounts of gankyrin, and it restores p53-dependent transcription and sensitivity to DNA damage
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$58In StockIn Stock
5 mg$143In StockIn Stock
10 mg$215In StockIn Stock
25 mg$387In StockIn Stock
50 mg$581In StockIn Stock
100 mg$810In StockIn Stock
200 mg$1,090In StockIn Stock
1 mL x 10 mM (in DMSO)$163In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Purity:99.56%
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COA HNMR LCMS

Product Introduction

Bioactivity
Description
Cjoc42 is an inhibitor of gankyrin, an ankyrin-repeat oncoprotein whose overexpression has been implicated in the development of many cancer types. cjoc42 prevents the decrease in p53 protein levels normally associated with high amounts of gankyrin, and it restores p53-dependent transcription and sensitivity to DNA damage
In vitro
cjoc42 (0.1, 1, and 10 μM) alone showed no dose-dependent change in cell viability. cjoc42 (0.5, 1, and 5 μM) inhibited gankyrin-induced lowering of p53 levels in cells.[1]
Synonymscjoc-42, cjoc 42
Chemical Properties
Molecular Weight415.46
FormulaC20H21N3O5S
Cas No.2171519-89-2
SmilesCOC(=O)c1ccc(cc1)-n1cc(CCCOS(=O)(=O)c2ccc(C)cc2)nn1
ColorWhite
AppearanceSolid
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 65 mg/mL (156.45 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+90% Corn Oil: 2.5 mg/mL (6.02 mM), Sonication is recommeded.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.4070 mL12.0349 mL24.0697 mL120.3485 mL
5 mM0.4814 mL2.4070 mL4.8139 mL24.0697 mL
10 mM0.2407 mL1.2035 mL2.4070 mL12.0349 mL
20 mM0.1203 mL0.6017 mL1.2035 mL6.0174 mL
50 mM0.0481 mL0.2407 mL0.4814 mL2.4070 mL
100 mM0.0241 mL0.1203 mL0.2407 mL1.2035 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
% DMSO
%
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

transcriptionp53MDM-2/p53InhibitorinhibitgankyrinDNA damagecjoc42
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