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(E/Z)-Demethoxycurcumin

Name: (E/Z)-Demethoxycurcumin
Brand: TargetMol
SKU: T4803
Price: 81 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T4803Cas No. 24939-17-1

(p-Hydroxycinnamoyl)feruloylmethane is found in Curcuma zedoaria and Etlingera elatior. It has a role as a metabolite, an antineoplastic agent and an anti-inflammatory agent.

(E/Z)-Demethoxycurcumin

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Purity: 98.76%

Catalog No. T4803Cas No. 24939-17-1

(p-Hydroxycinnamoyl)feruloylmethane is found in Curcuma zedoaria and Etlingera elatior. It has a role as a metabolite, an antineoplastic agent and an anti-inflammatory agent.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$81	In Stock	In Stock
5 mg	$197	In Stock	In Stock
10 mg	$278	In Stock	In Stock
25 mg	$473	In Stock	In Stock
50 mg	$678	In Stock	In Stock
100 mg	$948	-	In Stock
1 mL x 10 mM (in DMSO)	$196	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:98.76%

Appearance:Solid

Color:Red

Resource Download

COA HNMR HPLC

Product Introduction

(E/Z)-Demethoxycurcumin AI Summary

(E/Z)-Demethoxycurcumin exhibits diverse bioactivities and cytotoxic effects across various human cell lines. It demonstrates significant cytotoxicity as evident from MTT assay results with IC50 values of 92100 nM against MCF7 cells, 26300 nM against WRL68 cells, and 28200 nM against A549 cells, indicative of its potential to inhibit cell growth. Additionally, it reduces UPA expression in HT1080 cells with an IC50 of 7500 nM and increases MMP3 levels in MDA-MB-231 cells after 24 hours with an IC50 of 9000000 nM. (E/Z)-Demethoxycurcumin induces apoptosis in SKOV3 cells at various concentrations, showing 70.7% activity at 80 µM, 35.1% at 20 µM, and 51.5% at 40 µM after 48 hours. The compound also displays significant inhibitory activity against the SARS-CoV-2 3CL protease with a percentage inhibition of -6.76% at 20 µM, and exhibits a 0.28% inhibition rate of SARS-CoV-2 induced cytotoxicity in VERO-6 cells at 10 µM after 48 hours exposure. Furthermore, it inhibits Staphylococcus aureus SrtA enzyme activity with an IC50 of 70300 nM and has antibacterial activity with a MIC value greater than 543300 nM. In terms of enzyme inhibition, (E/Z)-Demethoxycurcumin acts as an inhibitor of human MAO-A with a Ki value of 910 nM and MAO-B with an IC50 of 2450 nM. Lastly, it shows cytotoxicity against human HepG2 cells with an IC50 of 11500 nM as measured by the CellTiter-Glo luminescent cell viability assay, highlighting its effectiveness in diminishing cell viability..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

(p-Hydroxycinnamoyl)feruloylmethane is found in Curcuma zedoaria and Etlingera elatior. It has a role as a metabolite, an antineoplastic agent and an anti-inflammatory agent.

Chemical Properties

Molecular Weight	338.35
Formula	C₂₀H₁₈O₅
Cas No.	24939-17-1
Smiles	COc1cc(C=CC(=O)CC(=O)C=Cc2ccc(O)cc2)ccc1O
Relative Density.	1.282g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (162.55 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9555 mL	14.7776 mL	29.5552 mL	147.7760 mL
5 mM	0.5911 mL	2.9555 mL	5.9110 mL	29.5552 mL
10 mM	0.2956 mL	1.4778 mL	2.9555 mL	14.7776 mL
20 mM	0.1478 mL	0.7389 mL	1.4778 mL	7.3888 mL
50 mM	0.0591 mL	0.2956 mL	0.5911 mL	2.9555 mL
100 mM	0.0296 mL	0.1478 mL	0.2956 mL	1.4778 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc