Shopping Cart

Your shopping cart is currently empty

Dibucaine hydrochloride

Name: Dibucaine hydrochloride
Brand: TargetMol
SKU: T0364L
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

😃Good

Catalog No. T0364LCas No. 61-12-1

Alias Dibucaine HCl, Cinchocaine hydrochloride, Cinchocaine HCl

Dibucaine hydrochloride (Cinchocaine hydrochloride), a long-acting local amide anestheticsis, is usually used for surface anesthesia.

Dibucaine hydrochloride

😃Good

Purity: 99.66%

Catalog No. T0364LAlias Dibucaine HCl, Cinchocaine hydrochloride, Cinchocaine HClCas No. 61-12-1

Dibucaine hydrochloride (Cinchocaine hydrochloride), a long-acting local amide anestheticsis, is usually used for surface anesthesia.

Pack Size	Price	USA Warehouse	Global Warehouse
200 mg	$30	-	In Stock
500 mg	$44	-	In Stock
1 g	$52	-	In Stock
1 mL x 10 mM (in DMSO)	$39	In Stock	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.66%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	Dibucaine hydrochloride (Cinchocaine hydrochloride), a long-acting local amide anestheticsis, is usually used for surface anesthesia.
In vitro	Dibucaine (Cinchocaine) HCl is one of the most potent and toxic of the long-acting local anesthetics. [1] Dibucaine (Cinchocaine) HCl blocks both the initiation and conduction of nerve impulses by decreasing the neuronal membrane's permeability to sodium ions. This reversibly stabilizes the membrane and inhibits depolarization, resulting in the failure of a propagated action potential and subsequent conduction blockade. [2]
Synonyms	Dibucaine HCl, Cinchocaine hydrochloride, Cinchocaine HCl

Chemical Properties

Molecular Weight	379.92
Formula	C₂₀H₃₀ClN₃O₂
Cas No.	61-12-1
Smiles	Cl.CCCCOc1cc(C(=O)NCCN(CC)CC)c2ccccc2n1
Relative Density.	1.071g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 71 mg/mL (186.88 mM), Sonication is recommended.

H2O: 70 mg/mL (184.25 mM), Sonication is recommended.

DMSO: 60 mg/mL (157.93 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.26 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO/H2O/Ethanol

	1mg	5mg	10mg	50mg
1 mM	2.6321 mL	13.1607 mL	26.3213 mL	131.6067 mL
5 mM	0.5264 mL	2.6321 mL	5.2643 mL	26.3213 mL
10 mM	0.2632 mL	1.3161 mL	2.6321 mL	13.1607 mL
20 mM	0.1316 mL	0.6580 mL	1.3161 mL	6.5803 mL
50 mM	0.0526 mL	0.2632 mL	0.5264 mL	2.6321 mL
100 mM	0.0263 mL	0.1316 mL	0.2632 mL	1.3161 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc