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CH 5450

Name: CH 5450
Brand: TargetMol
SKU: TP1012
Price: 48 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TP1012Cas No. 252557-97-4

Alias Z-Ile-Glu-Pro-Phe-Ome

CH 5450 (Z-Ile-Glu-Pro-Phe-Ome) is a short peptide inhibitor of chymase in the human heart.

CH 5450

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Purity: 95.93%

Catalog No. TP1012Alias Z-Ile-Glu-Pro-Phe-OmeCas No. 252557-97-4

CH 5450 (Z-Ile-Glu-Pro-Phe-Ome) is a short peptide inhibitor of chymase in the human heart.

Pack Size	Price	Availability
1 mg	$48	In Stock
5 mg	$119	In Stock
10 mg	$197	In Stock
25 mg	$331	In Stock
50 mg	$472	In Stock
100 mg	$642	In Stock
200 mg	$865	In Stock
1 mL x 10 mM (in DMSO)	$175	In Stock

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Batch Information

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Purity:95.93%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	CH 5450 (Z-Ile-Glu-Pro-Phe-Ome) is a short peptide inhibitor of chymase in the human heart.
Synonyms	Z-Ile-Glu-Pro-Phe-Ome

Chemical Properties

Molecular Weight	652.73
Formula	C₃₄H₄₄N₄O₉
Cas No.	252557-97-4
Smiles	CC[C@H](C)[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](CCC(O)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)OC
Relative Density.	1.251 g/cm3 (Predicted)
Sequence	Z-Ile-Glu-Pro-Phe-Ome
Sequence Short	ZIEPF-Ome

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 43 mg/mL (65.88 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (3.06 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.5320 mL	7.6601 mL	15.3203 mL	76.6014 mL
5 mM	0.3064 mL	1.5320 mL	3.0641 mL	15.3203 mL
10 mM	0.1532 mL	0.7660 mL	1.5320 mL	7.6601 mL
20 mM	0.0766 mL	0.3830 mL	0.7660 mL	3.8301 mL
50 mM	0.0306 mL	0.1532 mL	0.3064 mL	1.5320 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc