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Cilofexor

Name: Cilofexor
Brand: TargetMol
SKU: T7436
Price: 46 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T7436Cas No. 1418274-28-8

Cilofexor inhibits binding of a synthetic peptide, Cilofexor is a farnesoid X receptor (FXR) agonist.

Cilofexor

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Purity: 99.86%

Catalog No. T7436Cas No. 1418274-28-8

Cilofexor inhibits binding of a synthetic peptide, Cilofexor is a farnesoid X receptor (FXR) agonist.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$46	In Stock	In Stock
2 mg	$70	In Stock	In Stock
5 mg	$126	In Stock	In Stock
10 mg	$198	In Stock	In Stock
25 mg	$396	In Stock	In Stock
50 mg	$596	In Stock	In Stock
100 mg	$787	-	In Stock
200 mg	$1,070	-	In Stock
1 mL x 10 mM (in DMSO)	$161	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.86%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Cilofexor AI Summary

Cilofexor exhibits agonist activity at the FXR (Farnesoid X Receptor) with EC50 values of 15.0 nM and 41.0 nM in different assays. It has demonstrated variable effects on cell viability across different cell types: promoting growth in HEK293T cells with growth rates ranging from 0.54 to 1.0 and displaying a potential inhibitory effect on human fibroblast cells with a growth rate of -0.03 in one assay. Moreover, Cilofexor affects the thermal stability of various protein domains as evidenced by Thermal Shift Assay results, increasing stability for certain domains (e.g., start/stop: M1-K294 and P449-E759) and decreasing stability for others (e.g., start/stop: M1-L298 and N44-E168). These observations indicate that the bioactivity of Cilofexor is both cell-type and protein-domain dependent, suggesting potential modulatory effects on cellular growth and protein function..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Cilofexor inhibits binding of a synthetic peptide, Cilofexor is a farnesoid X receptor (FXR) agonist.
Targets&IC50	FXR:43 nM (EC50)

Chemical Properties

Molecular Weight	586.85
Formula	C₂₈H₂₂Cl₃N₃O₅
Cas No.	1418274-28-8
Smiles	OC(=O)c1ccnc(c1)N1CC(O)(C1)c1ccc(OCc2c(onc2-c2c(Cl)cccc2Cl)C2CC2)cc1Cl
Relative Density.	1.538 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 166.7 mg/mL (284.06 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (6.82 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7040 mL	8.5201 mL	17.0401 mL	85.2006 mL
5 mM	0.3408 mL	1.7040 mL	3.4080 mL	17.0401 mL
10 mM	0.1704 mL	0.8520 mL	1.7040 mL	8.5201 mL
20 mM	0.0852 mL	0.4260 mL	0.8520 mL	4.2600 mL
50 mM	0.0341 mL	0.1704 mL	0.3408 mL	1.7040 mL
100 mM	0.0170 mL	0.0852 mL	0.1704 mL	0.8520 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc