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RPW-24

Name: RPW-24
Brand: TargetMol
SKU: T7669
Price: 42 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T7669Cas No. 1001625-82-6

RPW-24 is a stimulator of host immune defenses, has antibacterial activity.

RPW-24

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🥰Excellent

Purity: 97.21%

Catalog No. T7669Cas No. 1001625-82-6

RPW-24 is a stimulator of host immune defenses, has antibacterial activity.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$42	In Stock	In Stock
5 mg	$103	In Stock	In Stock
10 mg	$133	In Stock	In Stock
25 mg	$223	In Stock	In Stock
50 mg	$321	In Stock	In Stock
100 mg	$490	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

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Purity:97.21%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

RPW-24 AI Summary

RPW-24 exhibits multiple bioactivities with significant potential for anti-malarial, anti-leishmanial, anti-trypanosomal, and anti-mycobacterial applications. It inhibits the proliferation of Plasmodium falciparum (3D7 strain) with an EC50 of 527.0 nM and drug-resistant W2 strain with an EC50 of 755.0 nM, demonstrating its effectiveness against both drug-susceptible and drug-resistant malaria strains. The compound also shows low cytotoxicity against Huh7 hepatocellular carcinoma cells with a CC50 of 8920.0 nM. Additionally, RPW-24 is active against Leishmania infantum with an IC50 of 4000.0 nM, Trypanosoma cruzi with an IC50 of 3809.44 nM, and Trypanosoma brucei strains with IC50 values ranging from 3346.97 nM to 6531.06 nM. Though it shows low activity against non-replicating Mycobacterium tuberculosis (Mtb) with an MIC90 > 100,000.0 nM, it exhibits moderate activity against replicating Mtb with an MIC90 of 24700.0 nM. The compound has a lower LD50 of 10.9 µM against HepG2 cells, indicating moderate toxicity, and effectively inhibits parasites like Cryptosporidium parvum with a 40.42% inhibition rate and Schistosoma mansoni somules at a concentration of 2.5 µM. RPW-24 displays substantial anti-HIV bioactivity against CCR5-tropic and CXCR4-tropic strains and cytotoxicity against U87-CD4-CXCR4 and U87-CD4-CCR5 cells. It also shows promising effects in inhibiting the proliferation of various cancer cell lines, including ovarian, renal, breast, colon, melanoma, leukemia, non-small cell lung cancer, prostate, and CNS cancers, with inhibition percentages ranging from 23% to over 100%. Further bioactivities include a significant inhibition of the hERG Kv11.1 channel with 85.0% inhibition at 11.1 µM, anti-babesial activity with IC50 values between 6310.0 nM and 16520.0 nM, inhibition of typical and atypical growth of S. cerevisiae strain JHY222, and moderate inhibition of Plasmodium falciparum gametocyte and ookinete development. While the compound exhibits limited protein kinase inhibition, it does exhibit an IC50 of 1105.0 nM against P. falciparum Dd2-luc strain and shows low potency against glucose transporter-deficient transgenic Leishmania Mexicana promastigotes. These diverse activities display the compound's potential as a broad-spectrum antiparasitic and therapeutic agent across various infectious and non-infectious disease models..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

RPW-24 is a stimulator of host immune defenses, has antibacterial activity.

Chemical Properties

Molecular Weight	284.74
Formula	C₁₅H₁₃ClN₄
Cas No.	1001625-82-6
Smiles	Cc1ccc(Nc2nc(N)c3ccccc3n2)cc1Cl
Relative Density.	1.378 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (158.04 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.5120 mL	17.5599 mL	35.1198 mL	175.5988 mL
5 mM	0.7024 mL	3.5120 mL	7.0240 mL	35.1198 mL
10 mM	0.3512 mL	1.7560 mL	3.5120 mL	17.5599 mL
20 mM	0.1756 mL	0.8780 mL	1.7560 mL	8.7799 mL
50 mM	0.0702 mL	0.3512 mL	0.7024 mL	3.5120 mL
100 mM	0.0351 mL	0.1756 mL	0.3512 mL	1.7560 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc