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BPH-715

Name: BPH-715
Brand: TargetMol
SKU: T14766
Price: 100 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T14766Cas No. 1059677-23-4

BPH-715 inhibits the liver-stage growth of P. falciparum with an IC50 of 10 μM for P. falciparum exoerythrocytic forms in HepG2 cells.

BPH-715

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Purity: 98.91%

Catalog No. T14766Cas No. 1059677-23-4

BPH-715 inhibits the liver-stage growth of P. falciparum with an IC50 of 10 μM for P. falciparum exoerythrocytic forms in HepG2 cells.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$100	-	In Stock
5 mg	$247	-	In Stock
10 mg	$372	-	In Stock
25 mg	$648	-	In Stock
50 mg	$975	-	In Stock
1 mL x 10 mM (in DMSO)	$272	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:98.91%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

BPH-715 AI Summary

BPH-715 is a bioactive molecule with a range of inhibitory properties and therapeutic potential. It inhibits human recombinant geranylgeranyl diphosphate synthase (GGPPS) with an IC50 of approximately 280.0 nM and farnesyl diphosphate synthase (FPPS) with an IC50 of 100.0 nM. The compound also shows considerable antimalarial activity, exhibiting inhibitory effects against Plasmodium berghei NK65 in human HepG2 cells, Plasmodium falciparum, and Plasmodium vivax, along with antiplasmodial properties. Its antibacterial activity is demonstrated through the inhibition of Candida albicans CAI-4, Escherichia coli (IC50 of 6.0 nM for OPPS), and Staphylococcus aureus (IC50 of 110.0 nM for HepPPS). Additionally, BPH-715 inhibits the growth of human MDA-MB-231 cells with an IC50 of 100.0 nM and showcases a significant therapeutic index and favorable log P value, indicating its potential as a promising bioactive compound against malaria and other infections..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

BPH-715 inhibits the liver-stage growth of P. falciparum with an IC50 of 10 μM for P. falciparum exoerythrocytic forms in HepG2 cells.

Chemical Properties

Molecular Weight	423.38
Formula	C₁₇H₃₁NO₇P₂
Cas No.	1059677-23-4
Smiles	C(C(P(=O)([O-])O)P(=O)(O)O)[N+]=1C=C(OCCCCCCCCCC)C=CC1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

0.5 M NaOH: 75 mg/mL (177.15 mM), when pH is adjusted to 11 with NaOH. Sonication is recommended.

DMSO: 4.5 mg/mL (10.63 mM), Sonication and heating to 60℃ are recommended.

Solution Preparation Table

DMSO/0.5 M NaOH

	1mg	5mg	10mg	50mg
1 mM	2.3619 mL	11.8097 mL	23.6194 mL	118.0972 mL
5 mM	0.4724 mL	2.3619 mL	4.7239 mL	23.6194 mL
10 mM	0.2362 mL	1.1810 mL	2.3619 mL	11.8097 mL

0.5 M NaOH

	1mg	5mg	10mg	50mg
20 mM	0.1181 mL	0.5905 mL	1.1810 mL	5.9049 mL
50 mM	0.0472 mL	0.2362 mL	0.4724 mL	2.3619 mL
100 mM	0.0236 mL	0.1181 mL	0.2362 mL	1.1810 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc