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Nigakinone
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Catalog No. TQ0264Cas No. 18110-86-6
Nigakinone, isolated from Kumu, is an alkaloid with the pharmacological activity.
Nigakinone
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Purity: 99.84%
Catalog No. TQ0264Cas No. 18110-86-6
Nigakinone, isolated from Kumu, is an alkaloid with the pharmacological activity.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $56 | In Stock | In Stock | |
| 5 mg | $147 | In Stock | In Stock | |
| 10 mg | $239 | In Stock | In Stock | |
| 25 mg | $395 | In Stock | In Stock | |
| 50 mg | $587 | In Stock | In Stock | |
| 100 mg | $838 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $137 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.84%
Appearance:Solid
Color:White to Yellow
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Product Introduction
Nigakinone AI Summary
Nigakinone is a bioactive compound demonstrating inhibitory effects on a diverse range of biological targets, including Schistosoma Mansoni Peroxiredoxins, JMJD2A-Tudor Domain, Histone Lysine Methyltransferase G9a, RanGTP induced Rango-Importin beta complex dissociation, Human Flap endonuclease 1 (FEN1), TGF-b, Glutaminase (GLS), TDP-43, USP1/UAF1, and factors related to Fibrous Dysplasia/McCune-Albright Syndrome. It also inhibits the enzyme PTP1B at a concentration of 100 µM, with an inhibition rate of 42.8%.
In addition to its inhibition profile, Nigakinone exhibits neuroprotective properties in cerebral ischemia-induced Mongolian gerbils. At a 100 mg/kg dose, it showed a passive avoidance test value of <= 40.0% and a protective effect on the density of surviving neurons in the CA1 subfields of the hippocampus, with an activity of 13.9%, suggesting potential therapeutic benefits in cerebral ischemia.
Furthermore, Nigakinone displays cytotoxicity against human CNE-2 cells with an IC50 value of 7.96 µg/mL, indicating a significant ability to reduce cell viability. This broad spectrum of activities underlines Nigakinone's potential as a multi-target therapeutic agent..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Nigakinone, isolated from Kumu, is an alkaloid with the pharmacological activity. |
| Molecular Weight | 266.25 |
| Formula | C15H10N2O3 |
| Cas No. | 18110-86-6 |
| Smiles | COc1c(O)c(=O)n2c3ccccc3c3ccnc1c23 |
| Relative Density. | 1.515 g/cm3 |
| Storage | keep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 8 mg/mL (30.05 mM), Sonication is recommended. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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