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LM10

Name: LM10
Brand: TargetMol
SKU: T4410
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T4410Cas No. 1316695-35-8

Selective tryptophan 2, 3-dioxygenase (TDO) inhibitor (IC50 values are 0.62 and 2 μM for human and mouse TDO, respectively). Exhibits selectivity for TDO over IDO, MAO-A, MAO-B, and a panel of receptors and transporters. Reduces growth of TDO-expressing P815 mastocytoma tumors in mice. Orally bioavailable.

LM10

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Purity: 99.94%

Catalog No. T4410Cas No. 1316695-35-8

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$48	In Stock	In Stock
50 mg	$88	In Stock	In Stock
100 mg	$148	In Stock	In Stock
200 mg	$221	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.94%

Appearance:Solid

Color:White to Yellow

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COA HNMR LCMS

Product Introduction

LM10 AI Summary

LM10 exhibits bioactivity primarily as an inhibitor of Tryptophan 2,3-dioxygenase (TDO) across various species and experimental conditions. It inhibits mouse TDO with an IC50 ranging from 1960.0 nM to 17,000 nM and human TDO with IC50 values reported between 620.0 nM to 28,000 nM. The compound shows little to no significant inhibition of IDO1 (Indoleamine 2,3-dioxygenase 1) in both mouse and human models, with concentrations required for inhibition exceeding 400,000.0 nM. LM10 also demonstrates cytotoxicity against multiple cell lines, including mouse P815B cells and human HepG2 cells, with LD50 values greater than 100.0 uM. It features notable chemical stability and solubility in phosphate-buffered saline and displays selective inhibition towards the TDO enzyme over other enzymes and receptors. Furthermore, the compound does not exhibit significant antifungal or antibacterial activity and maintains low hemolytic and cytotoxic profiles against specific cell lines, suggesting a favorable safety margin for potential therapeutic applications targeting TDO..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Selective tryptophan 2, 3-dioxygenase (TDO) inhibitor (IC50 values are 0.62 and 2 μM for human and mouse TDO, respectively). Exhibits selectivity for TDO over IDO, MAO-A, MAO-B, and a panel of receptors and transporters. Reduces growth of TDO-expressing P815 mastocytoma tumors in mice. Orally bioavailable.
Targets&IC50	TDO (human):0.62 μM, TDO (mouse):2 μM

Chemical Properties

Molecular Weight	229.21
Formula	C₁₁H₈FN₅
Cas No.	1316695-35-8
Smiles	Fc1ccc2c(\C=C\c3nnn[nH]3)c[nH]c2c1
Relative Density.	1.556 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 4.58 mg/mL (19.98 mM), Sonication is recommended.

DMSO: 70 mg/mL (305.4 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (8.73 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	4.3628 mL	21.8141 mL	43.6281 mL	218.1406 mL
5 mM	0.8726 mL	4.3628 mL	8.7256 mL	43.6281 mL
10 mM	0.4363 mL	2.1814 mL	4.3628 mL	21.8141 mL

DMSO

	1mg	5mg	10mg	50mg
20 mM	0.2181 mL	1.0907 mL	2.1814 mL	10.9070 mL
50 mM	0.0873 mL	0.4363 mL	0.8726 mL	4.3628 mL
100 mM	0.0436 mL	0.2181 mL	0.4363 mL	2.1814 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc