ACVR2B Protein, Human, Recombinant (GST)

Catalog No. TMPC-00064 Copy Product Info

ACVR2B Protein, Human, Recombinant (GST) is expressed in Baculovirus-Insect Cells. The accession number is Q13705.

ACVR2B Protein, Human, Recombinant (GST)

Catalog No. TMPC-00064

Copy Product Info

ACVR2B Protein, Human, Recombinant (GST) is expressed in Baculovirus-Insect Cells. The accession number is Q13705.

Pack Size	Price	USA Stock	Global Stock	Quantity
10 μg	$1,390	35 days	35 days

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Biological Activity	The specific activity of ACVR2B was determined to be 1.2 nmol /min/mg by ADP-Glo kinase assay.
Description	ACVR2B Protein, Human, Recombinant (GST) is expressed in Baculovirus-Insect Cells. The accession number is Q13705.
Species	Human
Expression System	Baculovirus-Insect Cells
Tag	N-GST
Accession Number	Q13705
Synonyms	ACVR2B,ACTR-IIB,Activin receptor type-2B,Activin receptor type IIB
Construction	Recombinant human ACVR2B (182-488) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Protein Purity	>85% as determined by SDS-PAGE.
Molecular Weight	~61 kDa
Formulation	Supplied as sterile 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol.
Stability & Storage	Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	Enzymes are highly recommended to be shipped at frozen temperature with dry ice. Shipment made at ambient temperature may seriously affect the activity of the ordered products.
Research Background	ACVR2A and ACVR2B are two activin type II receptors. ACVR2B is integral to the activin and myostatin signaling pathway. Ligands such as activin and myostatin bind to ACVR2A and ACVR2B. Myostatin, a negative regulator of skeletal muscle growth, is regarded as a potential therapeutic target and binds to ACVR2B effectively, and to a lesser extent, to ACVR2A. The structure of human ACVR2B kinase domain in complex with adenine establishes the conserved bilobal architecture consistent with all other catalytic kinase domains. Haplotype structure at the ACVR2B and follistatin loci may contribute to interindividual variation in skeletal muscle mass and strength. Defects in ACVR2B are a cause of left-right axis malformations.