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CIL56
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Catalog No. T4309Cas No. 300802-28-2
Alias CA3
CIL56 (CA3) is a small molecule that induces cellular ferroptosis through the production of iron-dependent reactive oxygen species (ROS). It also induces accumulation of long-chain saturated, monounsaturated, and polyunsaturated fatty acids in HT-1080 cells in vitro.HT-1080 cells lacking acetyl-CoA carboxylase 1 (ACC1), the rate-limiting enzyme in fatty acid synthesis, exhibit 5-fold resistance to CIL56 treatment, indicating ACC1 activity sensitizes cells to CIL56-induced cell death.
CIL56
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Purity: 99.91%
Catalog No. T4309Alias CA3Cas No. 300802-28-2
CIL56 (CA3) is a small molecule that induces cellular ferroptosis through the production of iron-dependent reactive oxygen species (ROS). It also induces accumulation of long-chain saturated, monounsaturated, and polyunsaturated fatty acids in HT-1080 cells in vitro.HT-1080 cells lacking acetyl-CoA carboxylase 1 (ACC1), the rate-limiting enzyme in fatty acid synthesis, exhibit 5-fold resistance to CIL56 treatment, indicating ACC1 activity sensitizes cells to CIL56-induced cell death.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $31 | In Stock | In Stock | |
| 2 mg | $44 | In Stock | In Stock | |
| 5 mg | $72 | In Stock | In Stock | |
| 10 mg | $117 | In Stock | In Stock | |
| 25 mg | $198 | In Stock | In Stock | |
| 50 mg | $315 | In Stock | In Stock | |
| 100 mg | $483 | In Stock | In Stock | |
| 1 mL x 10 mM (in DMSO) | $78 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.91%
Color:White
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Product Introduction
CIL56 AI Summary
CIL56 exhibits a wide range of bioactivities, making it a versatile compound for potential drug development and research. Its bioactivities include inhibition of Luciferase Translation or Activity in H4 Neuroglioblastoma Cells, modulation of Lamin A Splicing, and inhibition of HSD17B4 and Human Jumonji Domain Containing 2E (JMJD2E). Additionally, it acts as a modulator of miRNAs and/or activator of miR-21, enhances SMN2 Splice Variant Expression, and serves as an agonist of the Thyroid Stimulating Hormone Receptor. CIL56 also inhibits Tyrosyl-DNA Phosphodiesterase (TDP1) and Heat Shock Factor 1 (HSF1), as well as various enzymes such as Aldehyde Dehydrogenase 1, HPGD, DNA Polymerase Beta. It inhibits ROR gamma transcriptional activity, T-Type Calcium Channel, and ATXN expression, induces DNA re-replication in various cell lines, and inhibits the Hepatitis C Virus (HCV) and various cellular signaling pathways.
Notably, CIL56 inhibits Wnt/beta-catenin transcriptional activity in human HT-29 cells with an IC50 value of 990.0 nM, as assessed by TCF luciferase promoter reporter assay. It also shows cytotoxicity against human BJeLR cells overexpressing oncogenic RAS, though with an IC50 value greater than 1000.0 nM. These diverse bioactivities indicate that CIL56 has the potential for affecting numerous cellular processes and pathways, warranting further investigation for therapeutic applications..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | CIL56 (CA3) is a small molecule that induces cellular ferroptosis through the production of iron-dependent reactive oxygen species (ROS). It also induces accumulation of long-chain saturated, monounsaturated, and polyunsaturated fatty acids in HT-1080 cells in vitro.HT-1080 cells lacking acetyl-CoA carboxylase 1 (ACC1), the rate-limiting enzyme in fatty acid synthesis, exhibit 5-fold resistance to CIL56 treatment, indicating ACC1 activity sensitizes cells to CIL56-induced cell death. |
| Synonyms | CA3 |
| Molecular Weight | 489.61 |
| Formula | C23H27N3O5S2 |
| Cas No. | 300802-28-2 |
| Smiles | ON=C1c2cc(ccc2-c2ccc(cc12)S(=O)(=O)N1CCCCC1)S(=O)(=O)N1CCCCC1 |
| Relative Density. | 1.51 g/cm3 (Predicted) |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||
| Solubility Information | DMSO: 6.94 mg/mL (14.17 mM), Sonication is recommended.  | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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